The role of viral infectivity in oncolytic virotherapy outcomes: A mathematical study

A model capturing the dynamics between virus and tumour cells in the context of oncolytic virotherapy is presented and analysed. The ability of the virus to be internalised by uninfected cells is described by an infectivity parameter, which is inferred from available experimental data. The parameter...

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Veröffentlicht in:	Mathematical biosciences 2021-04, Vol.334, p.108520-108520, Article 108520
Hauptverfasser:	Pooladvand, Pantea, Yun, Chae-Ok, Yoon, A.-Rum, Kim, Peter S., Frascoli, Federico
Format:	Artikel
Sprache:	eng
Schlagworte:	Bifurcation theory Immunotherapy Infectivity Life span Mathematical models ODEs Oncolysis Oncolytic virotherapy Oscillations Parameters PDEs Tumors Vectors (mathematics) Viruses
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