Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

Mitochondrial respiration (oxidative phosphorylation, OXPHOS) is an emerging target in currently refractory cancers such as pancreatic ductal adenocarcinoma (PDAC). However, the variability of energetic metabolic adaptations between PDAC patients has not been assessed in functional investigations. I...

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Veröffentlicht in:	Cell reports. Medicine 2020-11, Vol.1 (8), p.100143-100143, Article 100143
Hauptverfasser:	Masoud, Rawand, Reyes-Castellanos, Gabriela, Lac, Sophie, Garcia, Julie, Dou, Samir, Shintu, Laetitia, Abdel Hadi, Nadine, Gicquel, Tristan, El Kaoutari, Abdessamad, Diémé, Binta, Tranchida, Fabrice, Cormareche, Laurie, Borge, Laurence, Gayet, Odile, Pasquier, Eddy, Dusetti, Nelson, Iovanna, Juan, Carrier, Alice
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer metabolism Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - genetics Cell Respiration - drug effects Cell Respiration - genetics Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Electron Transport Complex I - genetics energetic metabolism Female Gemcitabine Humans Life Sciences Male metabolic heterogeneity Mice Mice, Inbred C57BL Mice, Nude mitochondria Mitochondria - drug effects Mitochondria - genetics mitochondrial Complex I Oxidative Phosphorylation - drug effects OXPHOS pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics PC-3 Cells personalized medicine phenformin Phenformin - pharmacology therapeutic strategy Xenograft Model Antitumor Assays - methods
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