Supercritical-CO2 Foam Extrusion of Hydroxypropyl Methyl Cellulose Acetate Succinate/Itraconazole Amorphous Solid Dispersions: Processing-Structure-Property Relations

This study investigates the effects of supercritical CO2 as a foaming agent on structure and physical properties of hot melt extruded hydroxypropyl methylcellulose acetate succinate (HPMCAS)-itraconazole (ITZ) amorphous solid dispersions (ASDs) with the aim of improving the milling efficiency and ta...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2021-04, Vol.110 (4), p.1444-1456
Hauptverfasser:	Rahimi, Shahab Kashani, O’Donnell, Kevin, Haight, Brian, Machado, Augie, Martin, Charlie, Meng, Fan, Listro, Tony, Zhang, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous Solid Dispersion(s) (ASD) Bioavailability Compaction Extrusion Foaming Milling
Online-Zugang:	Volltext
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