Pathological mechanism of joint destruction in haemophilic arthropathy
Haemophilic arthropathy (HA), caused by intra-articular haemorrhage, is one of the most common complications in patients with haemophilia. Factor replacement therapy provides missing coagulation factors to prevent children with haemophilia from joint bleeding and decreases their risk for HA. However...
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| Veröffentlicht in: | Molecular biology reports 2021, Vol.48 (1), p.969-974 |
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| creator | Zhu, Haijia Meng, Yilin Tong, Peijian Zhang, Shanxing |
| description | Haemophilic arthropathy (HA), caused by intra-articular haemorrhage, is one of the most common complications in patients with haemophilia. Factor replacement therapy provides missing coagulation factors to prevent children with haemophilia from joint bleeding and decreases their risk for HA. However, haemophilia patients in developing countries are still suffering from HA due to insufficient replacement therapy. Symptoms such as pain and activity limitations caused by HA seriously affect the functional abilities and quality of life of patients with HA, causing a high disability rate in the haemophilia cohort. The pathological mechanism of HA is complicated because the whole pathological mainly involves hypertrophic synovitis, osteopenia, cartilage and bone destruction, and these pathological changes occur in parallel and interact with each other. Inflammation plays an important role in the whole complex pathological process, and iron, cytokines, growth factors and other factors are involved. This review summarizes the pathological mechanism of HA to provide background for clinical and basic research. |
| doi_str_mv | 10.1007/s11033-020-06052-8 |
| format | Article |
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Factor replacement therapy provides missing coagulation factors to prevent children with haemophilia from joint bleeding and decreases their risk for HA. However, haemophilia patients in developing countries are still suffering from HA due to insufficient replacement therapy. Symptoms such as pain and activity limitations caused by HA seriously affect the functional abilities and quality of life of patients with HA, causing a high disability rate in the haemophilia cohort. The pathological mechanism of HA is complicated because the whole pathological mainly involves hypertrophic synovitis, osteopenia, cartilage and bone destruction, and these pathological changes occur in parallel and interact with each other. Inflammation plays an important role in the whole complex pathological process, and iron, cytokines, growth factors and other factors are involved. 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Factor replacement therapy provides missing coagulation factors to prevent children with haemophilia from joint bleeding and decreases their risk for HA. However, haemophilia patients in developing countries are still suffering from HA due to insufficient replacement therapy. Symptoms such as pain and activity limitations caused by HA seriously affect the functional abilities and quality of life of patients with HA, causing a high disability rate in the haemophilia cohort. The pathological mechanism of HA is complicated because the whole pathological mainly involves hypertrophic synovitis, osteopenia, cartilage and bone destruction, and these pathological changes occur in parallel and interact with each other. Inflammation plays an important role in the whole complex pathological process, and iron, cytokines, growth factors and other factors are involved. This review summarizes the pathological mechanism of HA to provide background for clinical and basic research.</description><subject>Adult</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Arthritis - genetics</subject><subject>Arthritis - immunology</subject><subject>Arthritis - metabolism</subject><subject>Arthritis - pathology</subject><subject>Biomedical and Life Sciences</subject><subject>Bone Diseases, Metabolic - genetics</subject><subject>Bone Diseases, Metabolic - immunology</subject><subject>Bone Diseases, Metabolic - metabolism</subject><subject>Bone Diseases, Metabolic - pathology</subject><subject>Cartilage</subject><subject>Child</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Developing countries</subject><subject>Factor VIII - therapeutic use</subject><subject>Gene Expression Regulation</subject><subject>Growth factors</subject><subject>Hemarthrosis - genetics</subject><subject>Hemarthrosis - 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genetics</topic><topic>Arthritis - immunology</topic><topic>Arthritis - metabolism</topic><topic>Arthritis - pathology</topic><topic>Biomedical and Life Sciences</topic><topic>Bone Diseases, Metabolic - genetics</topic><topic>Bone Diseases, Metabolic - immunology</topic><topic>Bone Diseases, Metabolic - metabolism</topic><topic>Bone Diseases, Metabolic - pathology</topic><topic>Cartilage</topic><topic>Child</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Developing countries</topic><topic>Factor VIII - therapeutic use</topic><topic>Gene Expression Regulation</topic><topic>Growth factors</topic><topic>Hemarthrosis - genetics</topic><topic>Hemarthrosis - immunology</topic><topic>Hemarthrosis - metabolism</topic><topic>Hemarthrosis - pathology</topic><topic>Hemophilia</topic><topic>Hemophilia A - genetics</topic><topic>Hemophilia A - immunology</topic><topic>Hemophilia A - metabolism</topic><topic>Hemophilia A - pathology</topic><topic>Hemorrhage</topic><topic>Histology</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - 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Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Haijia</au><au>Meng, Yilin</au><au>Tong, Peijian</au><au>Zhang, Shanxing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathological mechanism of joint destruction in haemophilic arthropathy</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2021</date><risdate>2021</risdate><volume>48</volume><issue>1</issue><spage>969</spage><epage>974</epage><pages>969-974</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Haemophilic arthropathy (HA), caused by intra-articular haemorrhage, is one of the most common complications in patients with haemophilia. Factor replacement therapy provides missing coagulation factors to prevent children with haemophilia from joint bleeding and decreases their risk for HA. However, haemophilia patients in developing countries are still suffering from HA due to insufficient replacement therapy. Symptoms such as pain and activity limitations caused by HA seriously affect the functional abilities and quality of life of patients with HA, causing a high disability rate in the haemophilia cohort. The pathological mechanism of HA is complicated because the whole pathological mainly involves hypertrophic synovitis, osteopenia, cartilage and bone destruction, and these pathological changes occur in parallel and interact with each other. Inflammation plays an important role in the whole complex pathological process, and iron, cytokines, growth factors and other factors are involved. This review summarizes the pathological mechanism of HA to provide background for clinical and basic research.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33289909</pmid><doi>10.1007/s11033-020-06052-8</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9370-9593</orcidid></addata></record> |
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| subjects | Adult Animal Anatomy Animal Biochemistry Arthritis - genetics Arthritis - immunology Arthritis - metabolism Arthritis - pathology Biomedical and Life Sciences Bone Diseases, Metabolic - genetics Bone Diseases, Metabolic - immunology Bone Diseases, Metabolic - metabolism Bone Diseases, Metabolic - pathology Cartilage Child Cytokines Cytokines - genetics Cytokines - immunology Developing countries Factor VIII - therapeutic use Gene Expression Regulation Growth factors Hemarthrosis - genetics Hemarthrosis - immunology Hemarthrosis - metabolism Hemarthrosis - pathology Hemophilia Hemophilia A - genetics Hemophilia A - immunology Hemophilia A - metabolism Hemophilia A - pathology Hemorrhage Histology Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - immunology Iron - immunology Iron - metabolism Joints - immunology Joints - metabolism Joints - pathology LDCs Life Sciences Mini Review Article Morphology Osteonecrosis - genetics Osteonecrosis - immunology Osteonecrosis - metabolism Osteonecrosis - pathology Osteopenia Patients Quality of Life Synovitis Synovitis - genetics Synovitis - immunology Synovitis - metabolism Synovitis - pathology |
| title | Pathological mechanism of joint destruction in haemophilic arthropathy |
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