Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites

[Display omitted] Inflammatory bowel diseases (IBD) are kind of recurrent inflammatory issues that occur in the gastrointestinal tract, and currently clinical treatment is still unideal due to the complex pathogenesis of IBD. Basically, gut barrier dysfunction is triggered by gut microbiota dysbiosi...

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Veröffentlicht in:	Pharmacological research 2021-02, Vol.164, p.105358-105358, Article 105358
Hauptverfasser:	Jing, Wanghui, Dong, Sijing, Luo, Xialin, Liu, Jingjing, Wei, Bin, Du, Wei, Yang, Lin, Luo, Hua, Wang, Yitao, Wang, Sicen, Lu, Haitao
Format:	Artikel
Sprache:	eng
Schlagworte:	AhR activation Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Berberine Berberine - pharmacology Berberine - therapeutic use Caco-2 Cells Colitis - drug therapy Colitis - immunology Colitis - microbiology Colitis - pathology Colon - drug effects Colon - immunology Colon - pathology Cytokines - immunology Dextran Sulfate Gastrointestinal Microbiome gut barrier function Humans inflammatory bowel disease Male microbial tryptophan catabolites Peroxidase - immunology Rats Rats, Sprague-Dawley Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Tryptophan - metabolism
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