68GaGa-Pentixafor for PET Imaging of Vascular Expression of CXCR-4 as a Marker of Arterial Inflammation in HIV-Infected Patients: A Comparison with 18FFDG PET Imaging
People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose posi...
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| creator | Lawal, Ismaheel O Popoola, Gbenga O Mahapane, Johncy Kaufmann, Jens Davis, Cindy Ndlovu, Honest Maserumule, Letjie C Mokoala, Kgomotso M G Bouterfa, Hakim Wester, Hans-Jürgen Zeevaart, Jan Rijn Sathekge, Mike M |
| description | People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target-background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target-background ratio. We used Bland and Altman plots to measure the level of agreement |
| doi_str_mv | 10.3390/biom10121629 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_2468335996</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2468335996</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_24683359963</originalsourceid><addsrcrecordid>eNqVjs9Kw0AQhxdRsGhvPsAcvUSzuzUm3kpM0hyEIKX0Vsa4qav7J-4m2Cfqc7oBD706zPAbPj6YIeSGxnecZ_H9m7SaxpTRhGVnZMYYTSP2yLfnJ_slmXv_GYdKQzM-I8ckrbDCqBFmkAfsrINpmmINtca9NHuwHWzQt6NCB8Whd8J7ac2E823-Gi0APSC8oPsSbqJLNwgnUUFtOoVa4zDp0sCq3kSBiXYQ79AEHG76J1hCbnWPTvqg_cjhA2hals_V6RPX5KJD5cX8L6_IbVms81XUO_s9Cj_stPStUAqNsKPfsUWScv6QZQn_h_oLl5dldQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2468335996</pqid></control><display><type>article</type><title>68GaGa-Pentixafor for PET Imaging of Vascular Expression of CXCR-4 as a Marker of Arterial Inflammation in HIV-Infected Patients: A Comparison with 18FFDG PET Imaging</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Lawal, Ismaheel O ; Popoola, Gbenga O ; Mahapane, Johncy ; Kaufmann, Jens ; Davis, Cindy ; Ndlovu, Honest ; Maserumule, Letjie C ; Mokoala, Kgomotso M G ; Bouterfa, Hakim ; Wester, Hans-Jürgen ; Zeevaart, Jan Rijn ; Sathekge, Mike M</creator><creatorcontrib>Lawal, Ismaheel O ; Popoola, Gbenga O ; Mahapane, Johncy ; Kaufmann, Jens ; Davis, Cindy ; Ndlovu, Honest ; Maserumule, Letjie C ; Mokoala, Kgomotso M G ; Bouterfa, Hakim ; Wester, Hans-Jürgen ; Zeevaart, Jan Rijn ; Sathekge, Mike M</creatorcontrib><description>People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target-background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target-background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.</description><identifier>ISSN: 2218-273X</identifier><identifier>EISSN: 2218-273X</identifier><identifier>DOI: 10.3390/biom10121629</identifier><language>eng</language><ispartof>Biomolecules (Basel, Switzerland), 2020-12, Vol.10 (12)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Lawal, Ismaheel O</creatorcontrib><creatorcontrib>Popoola, Gbenga O</creatorcontrib><creatorcontrib>Mahapane, Johncy</creatorcontrib><creatorcontrib>Kaufmann, Jens</creatorcontrib><creatorcontrib>Davis, Cindy</creatorcontrib><creatorcontrib>Ndlovu, Honest</creatorcontrib><creatorcontrib>Maserumule, Letjie C</creatorcontrib><creatorcontrib>Mokoala, Kgomotso M G</creatorcontrib><creatorcontrib>Bouterfa, Hakim</creatorcontrib><creatorcontrib>Wester, Hans-Jürgen</creatorcontrib><creatorcontrib>Zeevaart, Jan Rijn</creatorcontrib><creatorcontrib>Sathekge, Mike M</creatorcontrib><title>68GaGa-Pentixafor for PET Imaging of Vascular Expression of CXCR-4 as a Marker of Arterial Inflammation in HIV-Infected Patients: A Comparison with 18FFDG PET Imaging</title><title>Biomolecules (Basel, Switzerland)</title><description>People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target-background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target-background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.</description><issn>2218-273X</issn><issn>2218-273X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqVjs9Kw0AQhxdRsGhvPsAcvUSzuzUm3kpM0hyEIKX0Vsa4qav7J-4m2Cfqc7oBD706zPAbPj6YIeSGxnecZ_H9m7SaxpTRhGVnZMYYTSP2yLfnJ_slmXv_GYdKQzM-I8ckrbDCqBFmkAfsrINpmmINtca9NHuwHWzQt6NCB8Whd8J7ac2E823-Gi0APSC8oPsSbqJLNwgnUUFtOoVa4zDp0sCq3kSBiXYQ79AEHG76J1hCbnWPTvqg_cjhA2hals_V6RPX5KJD5cX8L6_IbVms81XUO_s9Cj_stPStUAqNsKPfsUWScv6QZQn_h_oLl5dldQ</recordid><startdate>20201203</startdate><enddate>20201203</enddate><creator>Lawal, Ismaheel O</creator><creator>Popoola, Gbenga O</creator><creator>Mahapane, Johncy</creator><creator>Kaufmann, Jens</creator><creator>Davis, Cindy</creator><creator>Ndlovu, Honest</creator><creator>Maserumule, Letjie C</creator><creator>Mokoala, Kgomotso M G</creator><creator>Bouterfa, Hakim</creator><creator>Wester, Hans-Jürgen</creator><creator>Zeevaart, Jan Rijn</creator><creator>Sathekge, Mike M</creator><scope>7X8</scope></search><sort><creationdate>20201203</creationdate><title>68GaGa-Pentixafor for PET Imaging of Vascular Expression of CXCR-4 as a Marker of Arterial Inflammation in HIV-Infected Patients: A Comparison with 18FFDG PET Imaging</title><author>Lawal, Ismaheel O ; Popoola, Gbenga O ; Mahapane, Johncy ; Kaufmann, Jens ; Davis, Cindy ; Ndlovu, Honest ; Maserumule, Letjie C ; Mokoala, Kgomotso M G ; Bouterfa, Hakim ; Wester, Hans-Jürgen ; Zeevaart, Jan Rijn ; Sathekge, Mike M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_24683359963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lawal, Ismaheel O</creatorcontrib><creatorcontrib>Popoola, Gbenga O</creatorcontrib><creatorcontrib>Mahapane, Johncy</creatorcontrib><creatorcontrib>Kaufmann, Jens</creatorcontrib><creatorcontrib>Davis, Cindy</creatorcontrib><creatorcontrib>Ndlovu, Honest</creatorcontrib><creatorcontrib>Maserumule, Letjie C</creatorcontrib><creatorcontrib>Mokoala, Kgomotso M G</creatorcontrib><creatorcontrib>Bouterfa, Hakim</creatorcontrib><creatorcontrib>Wester, Hans-Jürgen</creatorcontrib><creatorcontrib>Zeevaart, Jan Rijn</creatorcontrib><creatorcontrib>Sathekge, Mike M</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Biomolecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lawal, Ismaheel O</au><au>Popoola, Gbenga O</au><au>Mahapane, Johncy</au><au>Kaufmann, Jens</au><au>Davis, Cindy</au><au>Ndlovu, Honest</au><au>Maserumule, Letjie C</au><au>Mokoala, Kgomotso M G</au><au>Bouterfa, Hakim</au><au>Wester, Hans-Jürgen</au><au>Zeevaart, Jan Rijn</au><au>Sathekge, Mike M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>68GaGa-Pentixafor for PET Imaging of Vascular Expression of CXCR-4 as a Marker of Arterial Inflammation in HIV-Infected Patients: A Comparison with 18FFDG PET Imaging</atitle><jtitle>Biomolecules (Basel, Switzerland)</jtitle><date>2020-12-03</date><risdate>2020</risdate><volume>10</volume><issue>12</issue><issn>2218-273X</issn><eissn>2218-273X</eissn><abstract>People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target-background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target-background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.</abstract><doi>10.3390/biom10121629</doi></addata></record> |
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| title | 68GaGa-Pentixafor for PET Imaging of Vascular Expression of CXCR-4 as a Marker of Arterial Inflammation in HIV-Infected Patients: A Comparison with 18FFDG PET Imaging |
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