Massive submacular haemorrhage in polypoidal choroidal vasculopathy versus typical neovascular age‐related macular degeneration
Purpose To investigate the incidence rate of massive submacular haemorrhage (SMH) and risk factors in polypoidal choroidal vasculopathy (PCV) and typical neovascular age‐related macular degeneration (tnAMD). Methods A total of 465 patients who were diagnosed with either PCV (n = 245) or tnAMD (n = 2...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2021-08, Vol.99 (5), p.e706-e714 |
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| creator | Cho, Soo Chang Cho, JoonHee Park, Kyu Hyung Woo, Se Joon |
| description | Purpose
To investigate the incidence rate of massive submacular haemorrhage (SMH) and risk factors in polypoidal choroidal vasculopathy (PCV) and typical neovascular age‐related macular degeneration (tnAMD).
Methods
A total of 465 patients who were diagnosed with either PCV (n = 245) or tnAMD (n = 220) from 2003 to 2014 were enrolled. Cumulative incidence of massive SMH in PCV and that in tnAMD were compared. Risk factors of massive SMH were also analysed.
Results
Massive SMH occurred in 32 patients (13.1%) with PCV and 9 patients (4.1%) with tnAMD. Incidence rates of massive SMH 5 and 10 years after the first visit were 11.1% and 29.9% in PCV and 4.3% and 9.9% in tnAMD, respectively. Incidence rates of massive SMH in PCV were significantly higher than those in tnAMD (hazard ratio [HR], 2.66; p = 0.007). Cox regression analysis revealed that mean number of photodynamic therapies (PDTs) per year (HR, 4.24; p |
| doi_str_mv | 10.1111/aos.14676 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2468330878</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2563468595</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3886-550bbea9cd13b8b28529d79c0ae71c034f926b26d89ac4f0276719a11e5621553</originalsourceid><addsrcrecordid>eNp1kc1O3DAQx62qCJaFQ1-gitQLHBb8ETvOEaHyIYH2QCtxsybOLBuUjVM72So3eAOekSfBS4ADEnPxSPPTb0b-E_KD0SMW6xhcOGKpytQ3MmGZlDORKf39o5e3O2Q3hHtKFVMq3SY7QnCdi1ROyOM1hFCtMQl9sQLb1-CTJeDKeb-EO0yqJmldPbSuKqFO7NL5sVtDiLBroVsOyRp96EPSDW1l46xBN46jKzqeH5481tBhmbxvKPEOG_TQVa7ZI1sLqAPuv71T8vfs95_Ti9nV_Pzy9ORqZoXWaiYlLQqE3JZMFLrgWvK8zHJLATNmqUgXOVcFV6XOwaYLyjOVsRwYQ6k4k1JMycHobb3712PozKoKFusa4r19MDxVWgiqMx3RX5_Qe9f7Jl5nuFQigjLfCA9HynoXgseFaX21Aj8YRs0mFxNzMa-5RPbnmzF-M5Yf5HsQETgegf9VjcPXJnMyvxmVLyQOmsA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2563468595</pqid></control><display><type>article</type><title>Massive submacular haemorrhage in polypoidal choroidal vasculopathy versus typical neovascular age‐related macular degeneration</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><creator>Cho, Soo Chang ; Cho, JoonHee ; Park, Kyu Hyung ; Woo, Se Joon</creator><creatorcontrib>Cho, Soo Chang ; Cho, JoonHee ; Park, Kyu Hyung ; Woo, Se Joon</creatorcontrib><description>Purpose
To investigate the incidence rate of massive submacular haemorrhage (SMH) and risk factors in polypoidal choroidal vasculopathy (PCV) and typical neovascular age‐related macular degeneration (tnAMD).
Methods
A total of 465 patients who were diagnosed with either PCV (n = 245) or tnAMD (n = 220) from 2003 to 2014 were enrolled. Cumulative incidence of massive SMH in PCV and that in tnAMD were compared. Risk factors of massive SMH were also analysed.
Results
Massive SMH occurred in 32 patients (13.1%) with PCV and 9 patients (4.1%) with tnAMD. Incidence rates of massive SMH 5 and 10 years after the first visit were 11.1% and 29.9% in PCV and 4.3% and 9.9% in tnAMD, respectively. Incidence rates of massive SMH in PCV were significantly higher than those in tnAMD (hazard ratio [HR], 2.66; p = 0.007). Cox regression analysis revealed that mean number of photodynamic therapies (PDTs) per year (HR, 4.24; p < 0.001), cluster type of polypoidal lesion (HR, 3.42; p = 0.003) in PCV, and mean number of anti‐VEGF injections per year (HR, 1.58; p < 0.001) in tnAMD were significantly associated with risk of massive SMH. For patients with severe vision loss, proportion of incident massive SMH was significantly higher in PCV (29.5%) than in tnAMD (6.9%, p < 0.001).
Conclusion
The incidence rate of massive SMH in eyes with PCV was about three times higher than that in eyes with tnAMD. Treatment methods that can reduce the incidence of massive SMH should be considered, especially for eyes with PCV.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.14676</identifier><identifier>PMID: 33289345</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Choroid - blood supply ; Choroid Diseases - complications ; Choroid Diseases - diagnosis ; Female ; Fluorescein Angiography - methods ; Follow-Up Studies ; Fundus Oculi ; Hemorrhage ; Humans ; Incidence ; incidence rate ; Macular degeneration ; Male ; massive submacular haemorrhage ; Patients ; polypoidal choroidal vasculopathy ; Polyps - complications ; Polyps - diagnosis ; Republic of Korea - epidemiology ; Retinal Hemorrhage - diagnosis ; Retinal Hemorrhage - epidemiology ; Retinal Hemorrhage - etiology ; Retrospective Studies ; Risk factors ; Tomography, Optical Coherence - methods ; typical neovascular age‐related macular degeneration ; Vascular diseases ; Vascular endothelial growth factor ; Visual Acuity ; Wet Macular Degeneration - complications ; Wet Macular Degeneration - diagnosis</subject><ispartof>Acta ophthalmologica (Oxford, England), 2021-08, Vol.99 (5), p.e706-e714</ispartof><rights>2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-550bbea9cd13b8b28529d79c0ae71c034f926b26d89ac4f0276719a11e5621553</citedby><cites>FETCH-LOGICAL-c3886-550bbea9cd13b8b28529d79c0ae71c034f926b26d89ac4f0276719a11e5621553</cites><orcidid>0000-0002-5516-8121 ; 0000-0003-3692-7169</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.14676$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.14676$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33289345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Soo Chang</creatorcontrib><creatorcontrib>Cho, JoonHee</creatorcontrib><creatorcontrib>Park, Kyu Hyung</creatorcontrib><creatorcontrib>Woo, Se Joon</creatorcontrib><title>Massive submacular haemorrhage in polypoidal choroidal vasculopathy versus typical neovascular age‐related macular degeneration</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To investigate the incidence rate of massive submacular haemorrhage (SMH) and risk factors in polypoidal choroidal vasculopathy (PCV) and typical neovascular age‐related macular degeneration (tnAMD).
Methods
A total of 465 patients who were diagnosed with either PCV (n = 245) or tnAMD (n = 220) from 2003 to 2014 were enrolled. Cumulative incidence of massive SMH in PCV and that in tnAMD were compared. Risk factors of massive SMH were also analysed.
Results
Massive SMH occurred in 32 patients (13.1%) with PCV and 9 patients (4.1%) with tnAMD. Incidence rates of massive SMH 5 and 10 years after the first visit were 11.1% and 29.9% in PCV and 4.3% and 9.9% in tnAMD, respectively. Incidence rates of massive SMH in PCV were significantly higher than those in tnAMD (hazard ratio [HR], 2.66; p = 0.007). Cox regression analysis revealed that mean number of photodynamic therapies (PDTs) per year (HR, 4.24; p < 0.001), cluster type of polypoidal lesion (HR, 3.42; p = 0.003) in PCV, and mean number of anti‐VEGF injections per year (HR, 1.58; p < 0.001) in tnAMD were significantly associated with risk of massive SMH. For patients with severe vision loss, proportion of incident massive SMH was significantly higher in PCV (29.5%) than in tnAMD (6.9%, p < 0.001).
Conclusion
The incidence rate of massive SMH in eyes with PCV was about three times higher than that in eyes with tnAMD. Treatment methods that can reduce the incidence of massive SMH should be considered, especially for eyes with PCV.</description><subject>Aged</subject><subject>Choroid - blood supply</subject><subject>Choroid Diseases - complications</subject><subject>Choroid Diseases - diagnosis</subject><subject>Female</subject><subject>Fluorescein Angiography - methods</subject><subject>Follow-Up Studies</subject><subject>Fundus Oculi</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Incidence</subject><subject>incidence rate</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>massive submacular haemorrhage</subject><subject>Patients</subject><subject>polypoidal choroidal vasculopathy</subject><subject>Polyps - complications</subject><subject>Polyps - diagnosis</subject><subject>Republic of Korea - epidemiology</subject><subject>Retinal Hemorrhage - diagnosis</subject><subject>Retinal Hemorrhage - epidemiology</subject><subject>Retinal Hemorrhage - etiology</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Tomography, Optical Coherence - methods</subject><subject>typical neovascular age‐related macular degeneration</subject><subject>Vascular diseases</subject><subject>Vascular endothelial growth factor</subject><subject>Visual Acuity</subject><subject>Wet Macular Degeneration - complications</subject><subject>Wet Macular Degeneration - diagnosis</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1O3DAQx62qCJaFQ1-gitQLHBb8ETvOEaHyIYH2QCtxsybOLBuUjVM72So3eAOekSfBS4ADEnPxSPPTb0b-E_KD0SMW6xhcOGKpytQ3MmGZlDORKf39o5e3O2Q3hHtKFVMq3SY7QnCdi1ROyOM1hFCtMQl9sQLb1-CTJeDKeb-EO0yqJmldPbSuKqFO7NL5sVtDiLBroVsOyRp96EPSDW1l46xBN46jKzqeH5481tBhmbxvKPEOG_TQVa7ZI1sLqAPuv71T8vfs95_Ti9nV_Pzy9ORqZoXWaiYlLQqE3JZMFLrgWvK8zHJLATNmqUgXOVcFV6XOwaYLyjOVsRwYQ6k4k1JMycHobb3712PozKoKFusa4r19MDxVWgiqMx3RX5_Qe9f7Jl5nuFQigjLfCA9HynoXgseFaX21Aj8YRs0mFxNzMa-5RPbnmzF-M5Yf5HsQETgegf9VjcPXJnMyvxmVLyQOmsA</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Cho, Soo Chang</creator><creator>Cho, JoonHee</creator><creator>Park, Kyu Hyung</creator><creator>Woo, Se Joon</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5516-8121</orcidid><orcidid>https://orcid.org/0000-0003-3692-7169</orcidid></search><sort><creationdate>202108</creationdate><title>Massive submacular haemorrhage in polypoidal choroidal vasculopathy versus typical neovascular age‐related macular degeneration</title><author>Cho, Soo Chang ; Cho, JoonHee ; Park, Kyu Hyung ; Woo, Se Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-550bbea9cd13b8b28529d79c0ae71c034f926b26d89ac4f0276719a11e5621553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Choroid - blood supply</topic><topic>Choroid Diseases - complications</topic><topic>Choroid Diseases - diagnosis</topic><topic>Female</topic><topic>Fluorescein Angiography - methods</topic><topic>Follow-Up Studies</topic><topic>Fundus Oculi</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Incidence</topic><topic>incidence rate</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>massive submacular haemorrhage</topic><topic>Patients</topic><topic>polypoidal choroidal vasculopathy</topic><topic>Polyps - complications</topic><topic>Polyps - diagnosis</topic><topic>Republic of Korea - epidemiology</topic><topic>Retinal Hemorrhage - diagnosis</topic><topic>Retinal Hemorrhage - epidemiology</topic><topic>Retinal Hemorrhage - etiology</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Tomography, Optical Coherence - methods</topic><topic>typical neovascular age‐related macular degeneration</topic><topic>Vascular diseases</topic><topic>Vascular endothelial growth factor</topic><topic>Visual Acuity</topic><topic>Wet Macular Degeneration - complications</topic><topic>Wet Macular Degeneration - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Soo Chang</creatorcontrib><creatorcontrib>Cho, JoonHee</creatorcontrib><creatorcontrib>Park, Kyu Hyung</creatorcontrib><creatorcontrib>Woo, Se Joon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Soo Chang</au><au>Cho, JoonHee</au><au>Park, Kyu Hyung</au><au>Woo, Se Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Massive submacular haemorrhage in polypoidal choroidal vasculopathy versus typical neovascular age‐related macular degeneration</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>99</volume><issue>5</issue><spage>e706</spage><epage>e714</epage><pages>e706-e714</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To investigate the incidence rate of massive submacular haemorrhage (SMH) and risk factors in polypoidal choroidal vasculopathy (PCV) and typical neovascular age‐related macular degeneration (tnAMD).
Methods
A total of 465 patients who were diagnosed with either PCV (n = 245) or tnAMD (n = 220) from 2003 to 2014 were enrolled. Cumulative incidence of massive SMH in PCV and that in tnAMD were compared. Risk factors of massive SMH were also analysed.
Results
Massive SMH occurred in 32 patients (13.1%) with PCV and 9 patients (4.1%) with tnAMD. Incidence rates of massive SMH 5 and 10 years after the first visit were 11.1% and 29.9% in PCV and 4.3% and 9.9% in tnAMD, respectively. Incidence rates of massive SMH in PCV were significantly higher than those in tnAMD (hazard ratio [HR], 2.66; p = 0.007). Cox regression analysis revealed that mean number of photodynamic therapies (PDTs) per year (HR, 4.24; p < 0.001), cluster type of polypoidal lesion (HR, 3.42; p = 0.003) in PCV, and mean number of anti‐VEGF injections per year (HR, 1.58; p < 0.001) in tnAMD were significantly associated with risk of massive SMH. For patients with severe vision loss, proportion of incident massive SMH was significantly higher in PCV (29.5%) than in tnAMD (6.9%, p < 0.001).
Conclusion
The incidence rate of massive SMH in eyes with PCV was about three times higher than that in eyes with tnAMD. Treatment methods that can reduce the incidence of massive SMH should be considered, especially for eyes with PCV.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33289345</pmid><doi>10.1111/aos.14676</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5516-8121</orcidid><orcidid>https://orcid.org/0000-0003-3692-7169</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Choroid - blood supply Choroid Diseases - complications Choroid Diseases - diagnosis Female Fluorescein Angiography - methods Follow-Up Studies Fundus Oculi Hemorrhage Humans Incidence incidence rate Macular degeneration Male massive submacular haemorrhage Patients polypoidal choroidal vasculopathy Polyps - complications Polyps - diagnosis Republic of Korea - epidemiology Retinal Hemorrhage - diagnosis Retinal Hemorrhage - epidemiology Retinal Hemorrhage - etiology Retrospective Studies Risk factors Tomography, Optical Coherence - methods typical neovascular age‐related macular degeneration Vascular diseases Vascular endothelial growth factor Visual Acuity Wet Macular Degeneration - complications Wet Macular Degeneration - diagnosis |
| title | Massive submacular haemorrhage in polypoidal choroidal vasculopathy versus typical neovascular age‐related macular degeneration |
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