Recovery Profiles after Concussion among Male Student-Athletes and Service Cadets with a Family History of Neurodegenerative Disease: Data from the NCAA-DoD CARE Consortium
Preliminary evidence indicates that genetic factors associated with having a family history of neurodegenerative disease (fhNDD) may predispose an individual to persistent symptoms and poorer cognitive performance after concussion. No previous study, however, longitudinally examined athletes with (+...
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| Veröffentlicht in: | Journal of neurotrauma 2021-02, Vol.38 (4), p.485-492 |
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| creator | Harrison, Adam T McAllister, Thomas McCrea, Michael Broglio, Steven P Moore, Robert D |
| description | Preliminary evidence indicates that genetic factors associated with having a family history of neurodegenerative disease (fhNDD) may predispose an individual to persistent symptoms and poorer cognitive performance after concussion. No previous study, however, longitudinally examined athletes with (+) and without (-) a fhNDD. Therefore, we aimed to compare clinical symptoms and cognitive performance of fhNDD+ and fhNDD- athletes at baseline and at multiple time points after concussion. Questionnaire data from the Concussion Assessment, Research and Education (CARE) Consortium were used to identify male athletes and cadets with (
= 51) and without (
= 102) a fhNDD (Alzheimer disease, Parkinson disease, mild cognitive impairment, and non-Alzheimer dementia). All athletes completed the SCAT3 symptom checklist and ImPACT test before their sport season and again within 24-48 h of injury, at the unrestricted return-to-play, and at six months post-concussion. Compared with fhNDD-, fhNDD+ individuals demonstrated greater decrements in visual memory (relative to baseline) 24-48 h post-injury (
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| doi_str_mv | 10.1089/neu.2020.7386 |
| format | Article |
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= 51) and without (
= 102) a fhNDD (Alzheimer disease, Parkinson disease, mild cognitive impairment, and non-Alzheimer dementia). All athletes completed the SCAT3 symptom checklist and ImPACT test before their sport season and again within 24-48 h of injury, at the unrestricted return-to-play, and at six months post-concussion. Compared with fhNDD-, fhNDD+ individuals demonstrated greater decrements in visual memory (relative to baseline) 24-48 h post-injury (
< 0.05,
= 0.18). In addition, a main effect of group was observed for impulse control. Compared with fhNDD- athletes, fhNDD+ individuals demonstrated greater decrements in impulse control, 24-48 h post-injury, at the return to play, and at six-month assessments (
< 0.01,
= 0.23). These findings suggest that male athletes with a fhNDD may exhibit greater decrements in cognitive performance after concussion. Small, subtle deficits in cognitive performance may still significantly hinder day-to-day function in student-athletes.</description><identifier>ISSN: 0897-7151</identifier><identifier>EISSN: 1557-9042</identifier><identifier>DOI: 10.1089/neu.2020.7386</identifier><identifier>PMID: 33280495</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Age ; Alzheimer's disease ; Athletes ; Body mass index ; Cognitive ability ; Concussion ; Consortia ; Dementia ; Dementia disorders ; Demographics ; Family medical history ; Gender differences ; Genetic factors ; Impulsive behavior ; Males ; Medical diagnosis ; Memory ; Mental disorders ; Mental health ; Military service ; Movement disorders ; Neurodegenerative diseases ; Parkinson's disease ; Recovery (Medical) ; Sports injuries ; Survival analysis</subject><ispartof>Journal of neurotrauma, 2021-02, Vol.38 (4), p.485-492</ispartof><rights>Copyright Mary Ann Liebert, Inc. Feb 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-826c79bdafe915274a8efab31c460249d8d3ecdf28fbf7a58857bdb096331b3c3</citedby><cites>FETCH-LOGICAL-c321t-826c79bdafe915274a8efab31c460249d8d3ecdf28fbf7a58857bdb096331b3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33280495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harrison, Adam T</creatorcontrib><creatorcontrib>McAllister, Thomas</creatorcontrib><creatorcontrib>McCrea, Michael</creatorcontrib><creatorcontrib>Broglio, Steven P</creatorcontrib><creatorcontrib>Moore, Robert D</creatorcontrib><creatorcontrib>CARE Consortium Investigators</creatorcontrib><title>Recovery Profiles after Concussion among Male Student-Athletes and Service Cadets with a Family History of Neurodegenerative Disease: Data from the NCAA-DoD CARE Consortium</title><title>Journal of neurotrauma</title><addtitle>J Neurotrauma</addtitle><description>Preliminary evidence indicates that genetic factors associated with having a family history of neurodegenerative disease (fhNDD) may predispose an individual to persistent symptoms and poorer cognitive performance after concussion. No previous study, however, longitudinally examined athletes with (+) and without (-) a fhNDD. Therefore, we aimed to compare clinical symptoms and cognitive performance of fhNDD+ and fhNDD- athletes at baseline and at multiple time points after concussion. Questionnaire data from the Concussion Assessment, Research and Education (CARE) Consortium were used to identify male athletes and cadets with (
= 51) and without (
= 102) a fhNDD (Alzheimer disease, Parkinson disease, mild cognitive impairment, and non-Alzheimer dementia). All athletes completed the SCAT3 symptom checklist and ImPACT test before their sport season and again within 24-48 h of injury, at the unrestricted return-to-play, and at six months post-concussion. Compared with fhNDD-, fhNDD+ individuals demonstrated greater decrements in visual memory (relative to baseline) 24-48 h post-injury (
< 0.05,
= 0.18). In addition, a main effect of group was observed for impulse control. Compared with fhNDD- athletes, fhNDD+ individuals demonstrated greater decrements in impulse control, 24-48 h post-injury, at the return to play, and at six-month assessments (
< 0.01,
= 0.23). These findings suggest that male athletes with a fhNDD may exhibit greater decrements in cognitive performance after concussion. Small, subtle deficits in cognitive performance may still significantly hinder day-to-day function in student-athletes.</description><subject>Age</subject><subject>Alzheimer's disease</subject><subject>Athletes</subject><subject>Body mass index</subject><subject>Cognitive ability</subject><subject>Concussion</subject><subject>Consortia</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Demographics</subject><subject>Family medical history</subject><subject>Gender differences</subject><subject>Genetic factors</subject><subject>Impulsive behavior</subject><subject>Males</subject><subject>Medical diagnosis</subject><subject>Memory</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Military service</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson's disease</subject><subject>Recovery (Medical)</subject><subject>Sports injuries</subject><subject>Survival analysis</subject><issn>0897-7151</issn><issn>1557-9042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkUtv1DAUhS0EosPAki2yxIZNBj-S2GEXZfqS-kAtrCPHvu64SuLWdgbNf-JHkqiPBau7uN85OtKH0GdKNpTI6vsI04YRRjaCy_INWtGiEFlFcvYWrea_yAQt6BH6EOM9IZSXTLxHR5wzSfKqWKG_N6D9HsIB_wzeuh4iVjZBwI0f9RSj8yNWgx_v8KXqAd-mycCYsjrtekgLPBp8C2HvNOBGGUgR_3FphxU-UYPrD_jMxeTnem_xFUzBG7iDEYJKbg946yKoCD_wViWFbfADTjvAV01dZ1u_xU19c7wsiT4kNw0f0Tur-gifnu8a_T45_tWcZRfXp-dNfZFpzmjKJCu1qDqjLFS0YCJXEqzqONV5SVheGWk4aGOZtJ0VqpCyEJ3pSFVyTjuu-Rp9e-p9CP5xgpjawUUNfa9G8FNsWV4KmYt8DqzR1__Qez-FcV43U7KkQhCZz1T2ROngYwxg24fgBhUOLSXtorGdNbaLxnbROPNfnlunbgDzSr944_8AHouaFA</recordid><startdate>20210215</startdate><enddate>20210215</enddate><creator>Harrison, Adam T</creator><creator>McAllister, Thomas</creator><creator>McCrea, Michael</creator><creator>Broglio, Steven P</creator><creator>Moore, Robert D</creator><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210215</creationdate><title>Recovery Profiles after Concussion among Male Student-Athletes and Service Cadets with a Family History of Neurodegenerative Disease: Data from the NCAA-DoD CARE Consortium</title><author>Harrison, Adam T ; McAllister, Thomas ; McCrea, Michael ; Broglio, Steven P ; Moore, Robert D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-826c79bdafe915274a8efab31c460249d8d3ecdf28fbf7a58857bdb096331b3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Alzheimer's disease</topic><topic>Athletes</topic><topic>Body mass index</topic><topic>Cognitive ability</topic><topic>Concussion</topic><topic>Consortia</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Demographics</topic><topic>Family medical history</topic><topic>Gender differences</topic><topic>Genetic factors</topic><topic>Impulsive behavior</topic><topic>Males</topic><topic>Medical diagnosis</topic><topic>Memory</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Military service</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson's disease</topic><topic>Recovery (Medical)</topic><topic>Sports injuries</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrison, Adam T</creatorcontrib><creatorcontrib>McAllister, Thomas</creatorcontrib><creatorcontrib>McCrea, Michael</creatorcontrib><creatorcontrib>Broglio, Steven P</creatorcontrib><creatorcontrib>Moore, Robert D</creatorcontrib><creatorcontrib>CARE Consortium Investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurotrauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrison, Adam T</au><au>McAllister, Thomas</au><au>McCrea, Michael</au><au>Broglio, Steven P</au><au>Moore, Robert D</au><aucorp>CARE Consortium Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recovery Profiles after Concussion among Male Student-Athletes and Service Cadets with a Family History of Neurodegenerative Disease: Data from the NCAA-DoD CARE Consortium</atitle><jtitle>Journal of neurotrauma</jtitle><addtitle>J Neurotrauma</addtitle><date>2021-02-15</date><risdate>2021</risdate><volume>38</volume><issue>4</issue><spage>485</spage><epage>492</epage><pages>485-492</pages><issn>0897-7151</issn><eissn>1557-9042</eissn><abstract>Preliminary evidence indicates that genetic factors associated with having a family history of neurodegenerative disease (fhNDD) may predispose an individual to persistent symptoms and poorer cognitive performance after concussion. No previous study, however, longitudinally examined athletes with (+) and without (-) a fhNDD. Therefore, we aimed to compare clinical symptoms and cognitive performance of fhNDD+ and fhNDD- athletes at baseline and at multiple time points after concussion. Questionnaire data from the Concussion Assessment, Research and Education (CARE) Consortium were used to identify male athletes and cadets with (
= 51) and without (
= 102) a fhNDD (Alzheimer disease, Parkinson disease, mild cognitive impairment, and non-Alzheimer dementia). All athletes completed the SCAT3 symptom checklist and ImPACT test before their sport season and again within 24-48 h of injury, at the unrestricted return-to-play, and at six months post-concussion. Compared with fhNDD-, fhNDD+ individuals demonstrated greater decrements in visual memory (relative to baseline) 24-48 h post-injury (
< 0.05,
= 0.18). In addition, a main effect of group was observed for impulse control. Compared with fhNDD- athletes, fhNDD+ individuals demonstrated greater decrements in impulse control, 24-48 h post-injury, at the return to play, and at six-month assessments (
< 0.01,
= 0.23). These findings suggest that male athletes with a fhNDD may exhibit greater decrements in cognitive performance after concussion. Small, subtle deficits in cognitive performance may still significantly hinder day-to-day function in student-athletes.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>33280495</pmid><doi>10.1089/neu.2020.7386</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of neurotrauma, 2021-02, Vol.38 (4), p.485-492 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Age Alzheimer's disease Athletes Body mass index Cognitive ability Concussion Consortia Dementia Dementia disorders Demographics Family medical history Gender differences Genetic factors Impulsive behavior Males Medical diagnosis Memory Mental disorders Mental health Military service Movement disorders Neurodegenerative diseases Parkinson's disease Recovery (Medical) Sports injuries Survival analysis |
| title | Recovery Profiles after Concussion among Male Student-Athletes and Service Cadets with a Family History of Neurodegenerative Disease: Data from the NCAA-DoD CARE Consortium |
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