Characterization of novel zebrafish MHC class I U lineage genes and their haplotype
Major histocompatibility complex (MHC) genes are essential for distinguishing between individuals in all jawed vertebrates. Although MHC class I (mhc1) genes in zebrafish comprise distinct haplotypes, not all members of the mhc1 gene family have been fully characterized. In this study, we report the...
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| Veröffentlicht in: | Developmental and comparative immunology 2021-03, Vol.116, p.103952-103952, Article 103952 |
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| container_title | Developmental and comparative immunology |
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| creator | Honjo, Yasuko Takano, Kosuke Ichinohe, Tatsuo |
| description | Major histocompatibility complex (MHC) genes are essential for distinguishing between individuals in all jawed vertebrates. Although MHC class I (mhc1) genes in zebrafish comprise distinct haplotypes, not all members of the mhc1 gene family have been fully characterized. In this study, we report the identification of two novel U lineage genes isolated from the WIK strain of zebrafish. These new mhc1 genes, named una and uoa, are located in tandem on chromosome 19 with >70% homology to previously isolated U genes. Sequencing of their neighboring genes revealed that una and uoa form a unique haplotype different from the previously known U lineage haplotypes. Additionally, we determined the expression profiles of U, Z, and L genes in three different tissues. These findings collectively suggest that mhc1 U lineage genes and their haplotypes in zebrafish are more divergent than previously considered, and their expression patterns vary significantly among different tissues.
•Two novel zebrafish major histocompatibility complex class I genes were isolated.•These new genes consist of a unique haplotype that was not previously identified.•Striking differences were found in expression profile of all zebrafish mhc1 genes. |
| doi_str_mv | 10.1016/j.dci.2020.103952 |
| format | Article |
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•Two novel zebrafish major histocompatibility complex class I genes were isolated.•These new genes consist of a unique haplotype that was not previously identified.•Striking differences were found in expression profile of all zebrafish mhc1 genes.</description><identifier>ISSN: 0145-305X</identifier><identifier>EISSN: 1879-0089</identifier><identifier>DOI: 10.1016/j.dci.2020.103952</identifier><identifier>PMID: 33279476</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Chromosome 19 ; Chromosomes ; Chromosomes - genetics ; Danio rerio ; Gene Expression ; Gene Order ; Gene sequencing ; Genes ; Genes, MHC Class I ; Haplotypes ; Histocompatibility Antigens Class I - genetics ; Homology ; Major histocompatibility complex ; Phylogeny ; Tissue Distribution ; Vertebrates ; Zebrafish ; Zebrafish - genetics ; Zebrafish - immunology ; Zebrafish Proteins - genetics</subject><ispartof>Developmental and comparative immunology, 2021-03, Vol.116, p.103952-103952, Article 103952</ispartof><rights>2020 The Author(s)</rights><rights>Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Mar 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-d3ab25d2bcce76c015f7b7c2db34a26c77c43c7d436b895f4d97a2375804a5e43</citedby><cites>FETCH-LOGICAL-c424t-d3ab25d2bcce76c015f7b7c2db34a26c77c43c7d436b895f4d97a2375804a5e43</cites><orcidid>0000-0002-0393-4066</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145305X20305073$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33279476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Honjo, Yasuko</creatorcontrib><creatorcontrib>Takano, Kosuke</creatorcontrib><creatorcontrib>Ichinohe, Tatsuo</creatorcontrib><title>Characterization of novel zebrafish MHC class I U lineage genes and their haplotype</title><title>Developmental and comparative immunology</title><addtitle>Dev Comp Immunol</addtitle><description>Major histocompatibility complex (MHC) genes are essential for distinguishing between individuals in all jawed vertebrates. Although MHC class I (mhc1) genes in zebrafish comprise distinct haplotypes, not all members of the mhc1 gene family have been fully characterized. In this study, we report the identification of two novel U lineage genes isolated from the WIK strain of zebrafish. These new mhc1 genes, named una and uoa, are located in tandem on chromosome 19 with >70% homology to previously isolated U genes. Sequencing of their neighboring genes revealed that una and uoa form a unique haplotype different from the previously known U lineage haplotypes. Additionally, we determined the expression profiles of U, Z, and L genes in three different tissues. These findings collectively suggest that mhc1 U lineage genes and their haplotypes in zebrafish are more divergent than previously considered, and their expression patterns vary significantly among different tissues.
•Two novel zebrafish major histocompatibility complex class I genes were isolated.•These new genes consist of a unique haplotype that was not previously identified.•Striking differences were found in expression profile of all zebrafish mhc1 genes.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Chromosome 19</subject><subject>Chromosomes</subject><subject>Chromosomes - genetics</subject><subject>Danio rerio</subject><subject>Gene Expression</subject><subject>Gene Order</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Genes, MHC Class I</subject><subject>Haplotypes</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Homology</subject><subject>Major histocompatibility complex</subject><subject>Phylogeny</subject><subject>Tissue Distribution</subject><subject>Vertebrates</subject><subject>Zebrafish</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish - immunology</subject><subject>Zebrafish Proteins - genetics</subject><issn>0145-305X</issn><issn>1879-0089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMoWi8P4EYCbtxMzT0zuJLiDRQXKrgLmeSMTZlOajIt6NM7perChWdzOPD9P4cPoWNKxpRQdT4bexfGjLD1zSvJttCIlroqCCmrbTQiVMiCE_m6h_ZznpFhSkp20R7nTFdCqxF6mkxtsq6HFD5tH2KHY4O7uIIWf0KdbBPyFD_cTrBrbc74Dr_gNnRg3wC_QQcZ287jfgoh4aldtLH_WMAh2mlsm-Hoex-gl-ur58ltcf94cze5vC-cYKIvPLc1k57VzoFWjlDZ6Fo75msuLFNOaye4015wVZeVbISvtGVcy5IIK0HwA3S26V2k-L6E3Jt5yA7a1nYQl9kwoXQpSCXKAT39g87iMnXDd4ZJohSTSpKBohvKpZhzgsYsUpjb9GEoMWvjZmYG42Zt3GyMD5mT7-ZlPQf_m_hRPAAXGwAGFasAyWQXoHPgQwLXGx_DP_VfVAaPXQ</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Honjo, Yasuko</creator><creator>Takano, Kosuke</creator><creator>Ichinohe, Tatsuo</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0393-4066</orcidid></search><sort><creationdate>202103</creationdate><title>Characterization of novel zebrafish MHC class I U lineage genes and their haplotype</title><author>Honjo, Yasuko ; Takano, Kosuke ; Ichinohe, Tatsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-d3ab25d2bcce76c015f7b7c2db34a26c77c43c7d436b895f4d97a2375804a5e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Chromosome 19</topic><topic>Chromosomes</topic><topic>Chromosomes - genetics</topic><topic>Danio rerio</topic><topic>Gene Expression</topic><topic>Gene Order</topic><topic>Gene sequencing</topic><topic>Genes</topic><topic>Genes, MHC Class I</topic><topic>Haplotypes</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Homology</topic><topic>Major histocompatibility complex</topic><topic>Phylogeny</topic><topic>Tissue Distribution</topic><topic>Vertebrates</topic><topic>Zebrafish</topic><topic>Zebrafish - genetics</topic><topic>Zebrafish - immunology</topic><topic>Zebrafish Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Honjo, Yasuko</creatorcontrib><creatorcontrib>Takano, Kosuke</creatorcontrib><creatorcontrib>Ichinohe, Tatsuo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental and comparative immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Honjo, Yasuko</au><au>Takano, Kosuke</au><au>Ichinohe, Tatsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of novel zebrafish MHC class I U lineage genes and their haplotype</atitle><jtitle>Developmental and comparative immunology</jtitle><addtitle>Dev Comp Immunol</addtitle><date>2021-03</date><risdate>2021</risdate><volume>116</volume><spage>103952</spage><epage>103952</epage><pages>103952-103952</pages><artnum>103952</artnum><issn>0145-305X</issn><eissn>1879-0089</eissn><abstract>Major histocompatibility complex (MHC) genes are essential for distinguishing between individuals in all jawed vertebrates. Although MHC class I (mhc1) genes in zebrafish comprise distinct haplotypes, not all members of the mhc1 gene family have been fully characterized. In this study, we report the identification of two novel U lineage genes isolated from the WIK strain of zebrafish. These new mhc1 genes, named una and uoa, are located in tandem on chromosome 19 with >70% homology to previously isolated U genes. Sequencing of their neighboring genes revealed that una and uoa form a unique haplotype different from the previously known U lineage haplotypes. Additionally, we determined the expression profiles of U, Z, and L genes in three different tissues. These findings collectively suggest that mhc1 U lineage genes and their haplotypes in zebrafish are more divergent than previously considered, and their expression patterns vary significantly among different tissues.
•Two novel zebrafish major histocompatibility complex class I genes were isolated.•These new genes consist of a unique haplotype that was not previously identified.•Striking differences were found in expression profile of all zebrafish mhc1 genes.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>33279476</pmid><doi>10.1016/j.dci.2020.103952</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0393-4066</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals Chromosome 19 Chromosomes Chromosomes - genetics Danio rerio Gene Expression Gene Order Gene sequencing Genes Genes, MHC Class I Haplotypes Histocompatibility Antigens Class I - genetics Homology Major histocompatibility complex Phylogeny Tissue Distribution Vertebrates Zebrafish Zebrafish - genetics Zebrafish - immunology Zebrafish Proteins - genetics |
| title | Characterization of novel zebrafish MHC class I U lineage genes and their haplotype |
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