Atorvastatin alleviates microglia-mediated neuroinflammation via modulating the microbial composition and the intestinal barrier function in ischemic stroke mice

Our previous work has shown that atorvastatin exerts anti-inflammatory properties in ischemic stroke, and recent studies have revealed that intestinal microbiota plays a vital role in the pathogenesis of stroke. However, it is not clear whether the anti-inflammatory effects of atorvastatin against i...

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Veröffentlicht in:	Free radical biology & medicine 2021-01, Vol.162, p.104-117
Hauptverfasser:	Zhang, Peipei, Zhang, Xiangjian, Huang, Yuanxiang, Chen, Junmin, Shang, Wenyan, Shi, Guang, Zhang, Lan, Zhang, Cong, Chen, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Atorvastatin Fecal transplant Gut homeostasis Neuroinflammation Short-chain fatty acids Stroke
Online-Zugang:	Volltext
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