Design, synthesis and biological activity of 1,4-quinone moiety attached to betulin derivatives as potent DT-diaphorase substrate

[Display omitted] •Synthesized a series of betulin-1,4-quinone hybrids.•NQO1 activity of obtained hybrids.•Evaluated anticancerinvitroactivity against panel of the humancell line.•Apoptosis study for selected compound.•Molecular docking showed the most possible interactions between hybrids and NQO1...

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Veröffentlicht in:	Bioorganic chemistry 2021-01, Vol.106, p.104478-104478, Article 104478
Hauptverfasser:	Kadela-Tomanek, Monika, Jastrzębska, Maria, Marciniec, Krzysztof, Chrobak, Elwira, Bębenek, Ewa, Latocha, Małgorzata, Kuśmierz, Dariusz, Boryczka, Stanisław
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Naphthoquinone 5,8-Quinolinedione Anticancer activity Betulin Molecular docking study NQO1 protein Triazole
Online-Zugang:	Volltext
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