Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond

Medulloblastoma (MB) is a highly malignant cerebellar tumor predominantly diagnosed during childhood. Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH subgroup MB (SHH-MB) accounts for nearly one-third of diagnoses. Extensive molecular analyses have identified biologically and...

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Veröffentlicht in:	Trends in genetics 2021-03, Vol.37 (3), p.235-250
Hauptverfasser:	Garcia-Lopez, Jesus, Kumar, Rahul, Smith, Kyle S., Northcott, Paul A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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