Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors

[Display omitted] •Choline compounds are highly increased in glioblastoma cells.•Choline is also an agonist of α7- and α9-containing nicotinic receptors.•Both choline and nicotine promote glioblastoma cell proliferation and survival.•These effects are blocked by specific nicotinic antagonists or α7-...

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Veröffentlicht in:	Pharmacological research 2021-01, Vol.163, p.105336-105336, Article 105336
Hauptverfasser:	Pucci, Susanna, Fasoli, Francesca, Moretti, Milena, Benfante, Roberta, Di Lascio, Simona, Viani, Paola, Daga, Antonio, Gordon, Thomas J., McIntosh, Michael, Zoli, Michele, Clementi, Francesco, Gotti, Cecilia
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT1 and ERK1/2 Gene silencing Glioblastoma cell lines Neuronal nicotinic receptors Proliferation
Online-Zugang:	Volltext
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