Molecular profile of pancreatic neuroendocrine neoplasms (PanNENs): Opportunities for personalized therapies

Pancreatic neuroendocrine neoplasms (panNENs) are the second most common epithelial tumors of the pancreas. Despite improvements in prognostic grading and staging systems, it remains a challenge to predict the clinical behavior of panNENs and the response to specific therapies given the high degree...

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Veröffentlicht in:	Cancer 2021-02, Vol.127 (3), p.345-353
Hauptverfasser:	Arakelyan, Jemma, Zohrabyan, Davit, Philip, Philip A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATRX Biomarkers Carcinoma Chromatin remodeling Customization DAXX Daxx protein Drug development Gene frequency Genes Heterogeneity mammalian target of rapamycin (mTOR) MEN1 Mutation Neoplasms Neuroendocrine tumors Oncology p53 Protein Pancreas Pancreatic cancer pancreatic neuroendocrine carcinoma pancreatic neuroendocrine neoplasms pancreatic neuroendocrine tumor Rapamycin Retinoblastoma Somatostatin Somatostatin receptors TOR protein Tumors Very Low Frequencies
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