RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

The mechanisms of cellular energy sensing and AMPK-mediated mTORC1 inhibition are not fully delineated. Here, we discover that RIPK1 promotes mTORC1 inhibition during energetic stress. RIPK1 is involved in mediating the interaction between AMPK and TSC2 and facilitate TSC2 phosphorylation at Ser1387...

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Veröffentlicht in:	Molecular cell 2021-01, Vol.81 (2), p.370-385.e7
Hauptverfasser:	Najafov, Ayaz, Luu, Hoang Son, Mookhtiar, Adnan K., Mifflin, Lauren, Xia, Hong-guang, Amin, Palak P., Ordureau, Alban, Wang, Huibing, Yuan, Junying
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism AMPK Animals Animals, Newborn Autophagy-Related Protein 5 - deficiency Autophagy-Related Protein 5 - genetics CASP8 Caspase 8 - genetics Caspase 8 - metabolism Cell Death - genetics Fas-Associated Death Domain Protein - deficiency Fas-Associated Death Domain Protein - genetics Gene Expression Regulation Glucose - antagonists & inhibitors Glucose - pharmacology HEK293 Cells HT29 Cells Humans Intestine, Large - drug effects Intestine, Large - metabolism Intestine, Large - pathology Jurkat Cells lysosome Lysosomes - drug effects Lysosomes - metabolism Lysosomes - pathology Mechanistic Target of Rapamycin Complex 1 - genetics Mechanistic Target of Rapamycin Complex 1 - metabolism Metformin - antagonists & inhibitors Metformin - pharmacology Mice Mice, Inbred C57BL Mice, Knockout MLKL mTORC1 neonatal lethality Phosphorylation Receptor-Interacting Protein Serine-Threonine Kinases - deficiency Receptor-Interacting Protein Serine-Threonine Kinases - genetics RIPK1 RIPK3 Signal Transduction Sirolimus - pharmacology TSC2 Tuberous Sclerosis Complex 2 Protein - genetics Tuberous Sclerosis Complex 2 Protein - metabolism
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