ACE2 in the renin-angiotensin system
In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin-angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the oc...
Gespeichert in:
| Veröffentlicht in: | Clinical science (1979) 2020-12, Vol.134 (23), p.3063-3078 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3078 |
|---|---|
| container_issue | 23 |
| container_start_page | 3063 |
| container_title | Clinical science (1979) |
| container_volume | 134 |
| creator | Verano-Braga, Thiago Martins, Ana Luiza Valle Motta-Santos, Daisy Campagnole-Santos, Maria José Santos, Robson Augusto Souza |
| description | In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin-angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its receptor AT1, with the RAS alternative or protective arm, formed mainly by the heptapeptides Ang-(1-7) and alamandine, and their receptors, Mas and MrgD, respectively. In this work we reviewed classical and modern literature to describe how ACE2 is a critical component of the protective arm, particularly in the context of the cardiac function, coagulation homeostasis and immune system. We also review recent literature to present a critical view of the role of ACE2 and RAS in the SARS-CoV-2 pandemic. |
| doi_str_mv | 10.1042/CS20200478 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2466775950</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2466775950</sourcerecordid><originalsourceid>FETCH-LOGICAL-c287t-886c6a0f622a23bdbf4a25f25ab1cbcdcaacb355aa57d04eeb3370e1e694f60d3</originalsourceid><addsrcrecordid>eNpFkEtLw0AUhQdRbKxu_AGShQsRonfuvNJlCfUBBRfqOsxMbjSSR80ki_77RlqVszhw-DiLj7FLDnccJN5nrwgIIE16xCIuDSSpEfqYRcClSBQin7GzEL4AUEw5ZTMhUEvJMWLXy2yFcdXGwyfFPbVVm9j2o-oGasO0hm0YqDlnJ6WtA10ces7eH1Zv2VOyfnl8zpbrxGNqhiRNtdcWSo1oUbjCldKiKlFZx73zhbfWO6GUtcoUIImcEAaIk17IUkMh5uxm_7vpu--RwpA3VfBU17albgw5Sq2NUQsFE3q7R33fhdBTmW_6qrH9NueQ_1jJ_61M8NXhd3QNFX_orwaxA7qSWsw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2466775950</pqid></control><display><type>article</type><title>ACE2 in the renin-angiotensin system</title><source>MEDLINE</source><source>Portland Press Electronic Journals</source><creator>Verano-Braga, Thiago ; Martins, Ana Luiza Valle ; Motta-Santos, Daisy ; Campagnole-Santos, Maria José ; Santos, Robson Augusto Souza</creator><creatorcontrib>Verano-Braga, Thiago ; Martins, Ana Luiza Valle ; Motta-Santos, Daisy ; Campagnole-Santos, Maria José ; Santos, Robson Augusto Souza</creatorcontrib><description>In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin-angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its receptor AT1, with the RAS alternative or protective arm, formed mainly by the heptapeptides Ang-(1-7) and alamandine, and their receptors, Mas and MrgD, respectively. In this work we reviewed classical and modern literature to describe how ACE2 is a critical component of the protective arm, particularly in the context of the cardiac function, coagulation homeostasis and immune system. We also review recent literature to present a critical view of the role of ACE2 and RAS in the SARS-CoV-2 pandemic.</description><identifier>ISSN: 0143-5221</identifier><identifier>EISSN: 1470-8736</identifier><identifier>DOI: 10.1042/CS20200478</identifier><identifier>PMID: 33264412</identifier><language>eng</language><publisher>England</publisher><subject>Angiotensin-Converting Enzyme 2 - drug effects ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; COVID-19 - drug therapy ; COVID-19 - virology ; Humans ; Oligopeptides - pharmacology ; Renin-Angiotensin System - drug effects ; Renin-Angiotensin System - physiology ; SARS-CoV-2 - drug effects ; SARS-CoV-2 - pathogenicity</subject><ispartof>Clinical science (1979), 2020-12, Vol.134 (23), p.3063-3078</ispartof><rights>2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-886c6a0f622a23bdbf4a25f25ab1cbcdcaacb355aa57d04eeb3370e1e694f60d3</citedby><cites>FETCH-LOGICAL-c287t-886c6a0f622a23bdbf4a25f25ab1cbcdcaacb355aa57d04eeb3370e1e694f60d3</cites><orcidid>0000-0002-3265-7838 ; 0000-0001-9483-4206</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3253,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33264412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verano-Braga, Thiago</creatorcontrib><creatorcontrib>Martins, Ana Luiza Valle</creatorcontrib><creatorcontrib>Motta-Santos, Daisy</creatorcontrib><creatorcontrib>Campagnole-Santos, Maria José</creatorcontrib><creatorcontrib>Santos, Robson Augusto Souza</creatorcontrib><title>ACE2 in the renin-angiotensin system</title><title>Clinical science (1979)</title><addtitle>Clin Sci (Lond)</addtitle><description>In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin-angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its receptor AT1, with the RAS alternative or protective arm, formed mainly by the heptapeptides Ang-(1-7) and alamandine, and their receptors, Mas and MrgD, respectively. In this work we reviewed classical and modern literature to describe how ACE2 is a critical component of the protective arm, particularly in the context of the cardiac function, coagulation homeostasis and immune system. We also review recent literature to present a critical view of the role of ACE2 and RAS in the SARS-CoV-2 pandemic.</description><subject>Angiotensin-Converting Enzyme 2 - drug effects</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>COVID-19 - drug therapy</subject><subject>COVID-19 - virology</subject><subject>Humans</subject><subject>Oligopeptides - pharmacology</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Renin-Angiotensin System - physiology</subject><subject>SARS-CoV-2 - drug effects</subject><subject>SARS-CoV-2 - pathogenicity</subject><issn>0143-5221</issn><issn>1470-8736</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AUhQdRbKxu_AGShQsRonfuvNJlCfUBBRfqOsxMbjSSR80ki_77RlqVszhw-DiLj7FLDnccJN5nrwgIIE16xCIuDSSpEfqYRcClSBQin7GzEL4AUEw5ZTMhUEvJMWLXy2yFcdXGwyfFPbVVm9j2o-oGasO0hm0YqDlnJ6WtA10ces7eH1Zv2VOyfnl8zpbrxGNqhiRNtdcWSo1oUbjCldKiKlFZx73zhbfWO6GUtcoUIImcEAaIk17IUkMh5uxm_7vpu--RwpA3VfBU17albgw5Sq2NUQsFE3q7R33fhdBTmW_6qrH9NueQ_1jJ_61M8NXhd3QNFX_orwaxA7qSWsw</recordid><startdate>20201211</startdate><enddate>20201211</enddate><creator>Verano-Braga, Thiago</creator><creator>Martins, Ana Luiza Valle</creator><creator>Motta-Santos, Daisy</creator><creator>Campagnole-Santos, Maria José</creator><creator>Santos, Robson Augusto Souza</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3265-7838</orcidid><orcidid>https://orcid.org/0000-0001-9483-4206</orcidid></search><sort><creationdate>20201211</creationdate><title>ACE2 in the renin-angiotensin system</title><author>Verano-Braga, Thiago ; Martins, Ana Luiza Valle ; Motta-Santos, Daisy ; Campagnole-Santos, Maria José ; Santos, Robson Augusto Souza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-886c6a0f622a23bdbf4a25f25ab1cbcdcaacb355aa57d04eeb3370e1e694f60d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angiotensin-Converting Enzyme 2 - drug effects</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>COVID-19 - drug therapy</topic><topic>COVID-19 - virology</topic><topic>Humans</topic><topic>Oligopeptides - pharmacology</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>Renin-Angiotensin System - physiology</topic><topic>SARS-CoV-2 - drug effects</topic><topic>SARS-CoV-2 - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verano-Braga, Thiago</creatorcontrib><creatorcontrib>Martins, Ana Luiza Valle</creatorcontrib><creatorcontrib>Motta-Santos, Daisy</creatorcontrib><creatorcontrib>Campagnole-Santos, Maria José</creatorcontrib><creatorcontrib>Santos, Robson Augusto Souza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical science (1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verano-Braga, Thiago</au><au>Martins, Ana Luiza Valle</au><au>Motta-Santos, Daisy</au><au>Campagnole-Santos, Maria José</au><au>Santos, Robson Augusto Souza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ACE2 in the renin-angiotensin system</atitle><jtitle>Clinical science (1979)</jtitle><addtitle>Clin Sci (Lond)</addtitle><date>2020-12-11</date><risdate>2020</risdate><volume>134</volume><issue>23</issue><spage>3063</spage><epage>3078</epage><pages>3063-3078</pages><issn>0143-5221</issn><eissn>1470-8736</eissn><abstract>In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin-angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its receptor AT1, with the RAS alternative or protective arm, formed mainly by the heptapeptides Ang-(1-7) and alamandine, and their receptors, Mas and MrgD, respectively. In this work we reviewed classical and modern literature to describe how ACE2 is a critical component of the protective arm, particularly in the context of the cardiac function, coagulation homeostasis and immune system. We also review recent literature to present a critical view of the role of ACE2 and RAS in the SARS-CoV-2 pandemic.</abstract><cop>England</cop><pmid>33264412</pmid><doi>10.1042/CS20200478</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-3265-7838</orcidid><orcidid>https://orcid.org/0000-0001-9483-4206</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-5221 |
| ispartof | Clinical science (1979), 2020-12, Vol.134 (23), p.3063-3078 |
| issn | 0143-5221 1470-8736 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2466775950 |
| source | MEDLINE; Portland Press Electronic Journals |
| subjects | Angiotensin-Converting Enzyme 2 - drug effects Angiotensin-Converting Enzyme Inhibitors - pharmacology COVID-19 - drug therapy COVID-19 - virology Humans Oligopeptides - pharmacology Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology SARS-CoV-2 - drug effects SARS-CoV-2 - pathogenicity |
| title | ACE2 in the renin-angiotensin system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T02%3A04%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=ACE2%20in%20the%20renin-angiotensin%20system&rft.jtitle=Clinical%20science%20(1979)&rft.au=Verano-Braga,%20Thiago&rft.date=2020-12-11&rft.volume=134&rft.issue=23&rft.spage=3063&rft.epage=3078&rft.pages=3063-3078&rft.issn=0143-5221&rft.eissn=1470-8736&rft_id=info:doi/10.1042/CS20200478&rft_dat=%3Cproquest_cross%3E2466775950%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2466775950&rft_id=info:pmid/33264412&rfr_iscdi=true |