Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts

Bone morphogenetic protein (BMP) 9 is one of the most osteogenic BMPs, but its mechanism of action has not been fully elucidated. Hes1, a transcriptional regulator with a basic helix‐loop‐helix domain, is a well‐known effector of Notch signaling. Here, we find that BMP9 induces periodic increases of...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	FEBS letters 2021-02, Vol.595 (3), p.389-403
Hauptverfasser:	Seong, Chang‐Hwan, Chiba, Norika, Kusuyama, Joji, Subhan Amir, Muhammad, Eiraku, Nahoko, Yamashita, Sachiko, Ohnishi, Tomokazu, Nakamura, Norifumi, Matsuguchi, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Morphogenetic Protein 9 bone regeneration Hes1 notch osteogenic differentiation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!