Exploration of the nitrogen heterocyclic periphery around the core of the advanced FFA1 agonist fasiglifam (TAK‐875)

Three types of heterocyclic moieties—piperidines fused to a heteroaromatic moiety—were explored as potential periphery motifs for the pharmacophoric core of fasiglifam (TAK‐875), with fasiglifam being the most advanced agonist of free fatty acid receptor 1, a promising target for therapeutic interve...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2021-04, Vol.354 (4), p.e2000275-n/a
Hauptverfasser:	Lukin, Alexey, Bakholdina, Anna, Zhurilo, Nikolay, Onopchenko, Oleksandra, Zhuravel, Elena, Zozulya, Sergey, Gureev, Maxim, Safrygin, Alexander, Krasavin, Mikhail
Format:	Artikel
Sprache:	eng
Schlagworte:	Diabetes Fatty acids FFA1 receptor free fatty acids glucose‐stimulated insulin secretion GPR40 heterocyclic periphery Hyperglycemia Neuroendocrine tumors Pharmacology type 2 diabetes mellitus
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