Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells

Cancer stem cells (CSCs) are involved in the resistance of estrogen (ER)-positive breast tumors against endocrine therapy. On the other hand, nitric oxide (NO) plays a relevant role in CSC biology, although there are no studies addressing how this important signaling molecule may contribute to resis...

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Veröffentlicht in:	Laboratory investigation 2021-03, Vol.101 (3), p.292-303
Hauptverfasser:	López-Sánchez, Laura M., Mena, Rafael, Guil-Luna, Silvia, Mantrana, Ana, Peñarando, Jon, Toledano-Fonseca, Marta, Conde, Francisco, De la Haba-Rodríguez, Juan R., Aranda, Enrique, Rodríguez-Ariza, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/89 38/77 631/67/1059/2326 64/60 692/699/67/1347 82/51 Animals Anticancer properties Antineoplastic Agents, Hormonal - pharmacology Antineoplastic Agents, Hormonal - therapeutic use Biology Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer therapies Cell Line, Tumor Depletion Endocrine therapy Estrogen receptors Estrogens Female Gene expression Gene Silencing Humans Immunodeficiency Laboratory Medicine Medicine Medicine & Public Health Metastases Mice Mice, Inbred NOD Mice, SCID Neoplastic Stem Cells - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide - pharmacology Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Notch1 protein Pathology Receptors, Estrogen - metabolism Sensitivity analysis Signal Transduction - drug effects Stem cell transplantation Stem cells Subpopulations Survival Tamoxifen Tamoxifen - pharmacology Tamoxifen - therapeutic use Therapy Tumors
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