Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity

Impaired glucose tolerance associated with obesity causes postprandial hyperglycemia and can lead to type 2 diabetes. To study the differences in liver metabolism in healthy and obese states, we constructed and analyzed transomics glucose-responsive metabolic networks with layers for metabolites, ex...

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Veröffentlicht in:	Science signaling 2020-12, Vol.13 (660)
Hauptverfasser:	Kokaji, Toshiya, Hatano, Atsushi, Ito, Yuki, Yugi, Katsuyuki, Eto, Miki, Morita, Keigo, Ohno, Satoshi, Fujii, Masashi, Hironaka, Ken-Ichi, Egami, Riku, Terakawa, Akira, Tsuchiya, Takaho, Ozaki, Haruka, Inoue, Hiroshi, Uda, Shinsuke, Kubota, Hiroyuki, Suzuki, Yutaka, Ikeda, Kazutaka, Arita, Makoto, Matsumoto, Masaki, Nakayama, Keiichi I, Hirayama, Akiyoshi, Soga, Tomoyoshi, Kuroda, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Allosteric properties Amino acids Animal models Carbohydrates Data integration Diabetes mellitus (non-insulin dependent) Enzymes Gene expression Gene regulation Genes Glucose Glucose metabolism Glucose tolerance Homeostasis Hyperglycemia Insulin Leptin Lipids Liver Metabolic networks Metabolic response Metabolism Metabolites Network analysis Obesity Oral administration Phosphorylation Proteins Signal transduction Signaling Substrates Transcription factors
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