Adrenomedullin 2 attenuates LPS-induced inflammation in microglia cells by receptor-mediated cAMP-PKA pathway

Inflammation plays a critical role in the development of neurodegenerative diseases. Adrenomedullin 2 (AM2), a member of the calcitonin gene-related peptide family, has been known to have anti-inflammatory effects. Here, we evaluated the anti-inflammatory effects of AM2 in LPS-activated microglia an...

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Veröffentlicht in:	Neuropeptides (Edinburgh) 2021-02, Vol.85, p.102109-102109, Article 102109
Hauptverfasser:	Sun, Jing, Qian, Pei, Kang, Ying, Dai, Hang-Bing, Wang, Fang-Zheng, Wang, Hong-Yu, Zhou, Hong, Gao, Qing, Zhou, Ye-Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Adrenomedullin 2 Adrenomedullin receptor Animals Calcitonin gene-related peptide Cells, Cultured Cyclic AMP Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cyclooxygenase-2 IL-1β Inflammation Inflammation - metabolism Inflammation Mediators - metabolism Kinases Lipopolysaccharides Lipopolysaccharides - administration & dosage Microglia Microglia - metabolism mRNA Neurodegenerative diseases Nitric-oxide synthase Polymerase chain reaction Protein kinase A Proteins Rats Rats, Sprague-Dawley Receptor activity modifying proteins Receptors, Cyclic AMP - metabolism Signal Transduction Tumor necrosis factor-TNF Tumor necrosis factor-α
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