Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes

Intracellular methicillin-resistant Staphylococcus aureus (MRSA) is extremely difficult to remove by common antibiotics, leading to infection recurrence and resistance. Herein we report a novel exosome-based antibiotic delivery platform for eradicating intracellular MRSA, where mannosylated exosome...

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Veröffentlicht in:	Journal of controlled release 2021-01, Vol.329, p.454-467
Hauptverfasser:	Yang, Xiaohong, Xie, Beibei, Peng, Haibo, Shi, Gongming, Sreenivas, Banne, Guo, Jian, Wang, Chenhui, He, Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Exosomes Intracellular infection Surface functionalization Targeted delivery
Online-Zugang:	Volltext
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