Placental transverse relaxation time (T2) estimated by MRI: Normal values and the correlation with birthweight
Introduction Placental transverse relaxation time (T2) assessed by MRI may have the potential to improve the antenatal identification of small for gestational age. The aims of this study were to provide normal values of placental T2 in relation to gestational age at the time of MRI and to explore th...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 2021-05, Vol.100 (5), p.934-940 |
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| creator | Anderson, Kristi B. Andersen, Anna S. Hansen, Ditte N. Sinding, Marianne Peters, David A. Frøkjær, Jens B. Sørensen, Anne |
| description | Introduction
Placental transverse relaxation time (T2) assessed by MRI may have the potential to improve the antenatal identification of small for gestational age. The aims of this study were to provide normal values of placental T2 in relation to gestational age at the time of MRI and to explore the correlation between placental T2 and birthweight.
Material and methods
A mixed cohort of 112 singleton pregnancies was retrieved from our placental MRI research database. MRI was performed at 23.6‐41.3 weeks of gestation in a 1.5T system (TE (8): 50‐440 ms, TR: 4000 ms). Normal pregnancies were defined by uncomplicated pregnancies with normal obstetric outcome and birthweight deviation within ±1 SD of the expected for gestational age. The correlation between placental T2 and birthweight was investigated using the following outcomes; small for gestational age (birthweight ≤−2 SD of the expected for gestational age) and birthweight deviation (birthweight Z‐scores).
Results
In normal pregnancies (n = 27), placenta T2 showed a significant negative linear correlation with gestational age (r = −.91, P = .0001) being 184 ms ± 15.94 ms (mean ± SD) at 20 weeks of gestation and 89 ms ± 15.94 ms at 40 weeks of gestation. Placental T2 was significantly reduced among small‐for‐gestational‐age pregnancies (mean Z‐score −1.95, P |
| doi_str_mv | 10.1111/aogs.14057 |
| format | Article |
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Placental transverse relaxation time (T2) assessed by MRI may have the potential to improve the antenatal identification of small for gestational age. The aims of this study were to provide normal values of placental T2 in relation to gestational age at the time of MRI and to explore the correlation between placental T2 and birthweight.
Material and methods
A mixed cohort of 112 singleton pregnancies was retrieved from our placental MRI research database. MRI was performed at 23.6‐41.3 weeks of gestation in a 1.5T system (TE (8): 50‐440 ms, TR: 4000 ms). Normal pregnancies were defined by uncomplicated pregnancies with normal obstetric outcome and birthweight deviation within ±1 SD of the expected for gestational age. The correlation between placental T2 and birthweight was investigated using the following outcomes; small for gestational age (birthweight ≤−2 SD of the expected for gestational age) and birthweight deviation (birthweight Z‐scores).
Results
In normal pregnancies (n = 27), placenta T2 showed a significant negative linear correlation with gestational age (r = −.91, P = .0001) being 184 ms ± 15.94 ms (mean ± SD) at 20 weeks of gestation and 89 ms ± 15.94 ms at 40 weeks of gestation. Placental T2 was significantly reduced among small‐for‐gestational‐age pregnancies (mean Z‐score −1.95, P < .001). Moreover, we found a significant positive correlation between placenta T2 deviation (Z‐score) and birthweight deviation (Z‐score) (R2 = .26, P = .0001).
Conclusions
This study provides normal values of placental T2 to be used in future studies on placental MRI. Placental T2 is closely related to birthweight and may improve the antenatal identification of small‐for‐gestational‐age pregnancies.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1111/aogs.14057</identifier><identifier>PMID: 33258106</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>fetal monitoring ; Gestational age ; Growth disorders ; Health risks ; high‐risk pregnancy ; Magnetic resonance imaging ; Medical diagnosis ; Placenta ; placental transverse relaxation time ; Pregnancy ; Prenatal development ; prenatal diagnosis</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 2021-05, Vol.100 (5), p.934-940</ispartof><rights>2020 Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). Published by John Wiley & Sons Ltd</rights><rights>2020 Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 Acta Obstetricia et Gynecologica Scandinavica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3937-ce4e0997718f6ea5e8f96d73e83fd22323daf684d0d0be24dae4ae0225005b4e3</citedby><cites>FETCH-LOGICAL-c3937-ce4e0997718f6ea5e8f96d73e83fd22323daf684d0d0be24dae4ae0225005b4e3</cites><orcidid>0000-0002-1680-1879 ; 0000-0002-0866-6654</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faogs.14057$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faogs.14057$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33258106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Kristi B.</creatorcontrib><creatorcontrib>Andersen, Anna S.</creatorcontrib><creatorcontrib>Hansen, Ditte N.</creatorcontrib><creatorcontrib>Sinding, Marianne</creatorcontrib><creatorcontrib>Peters, David A.</creatorcontrib><creatorcontrib>Frøkjær, Jens B.</creatorcontrib><creatorcontrib>Sørensen, Anne</creatorcontrib><title>Placental transverse relaxation time (T2) estimated by MRI: Normal values and the correlation with birthweight</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Introduction
Placental transverse relaxation time (T2) assessed by MRI may have the potential to improve the antenatal identification of small for gestational age. The aims of this study were to provide normal values of placental T2 in relation to gestational age at the time of MRI and to explore the correlation between placental T2 and birthweight.
Material and methods
A mixed cohort of 112 singleton pregnancies was retrieved from our placental MRI research database. MRI was performed at 23.6‐41.3 weeks of gestation in a 1.5T system (TE (8): 50‐440 ms, TR: 4000 ms). Normal pregnancies were defined by uncomplicated pregnancies with normal obstetric outcome and birthweight deviation within ±1 SD of the expected for gestational age. The correlation between placental T2 and birthweight was investigated using the following outcomes; small for gestational age (birthweight ≤−2 SD of the expected for gestational age) and birthweight deviation (birthweight Z‐scores).
Results
In normal pregnancies (n = 27), placenta T2 showed a significant negative linear correlation with gestational age (r = −.91, P = .0001) being 184 ms ± 15.94 ms (mean ± SD) at 20 weeks of gestation and 89 ms ± 15.94 ms at 40 weeks of gestation. Placental T2 was significantly reduced among small‐for‐gestational‐age pregnancies (mean Z‐score −1.95, P < .001). Moreover, we found a significant positive correlation between placenta T2 deviation (Z‐score) and birthweight deviation (Z‐score) (R2 = .26, P = .0001).
Conclusions
This study provides normal values of placental T2 to be used in future studies on placental MRI. Placental T2 is closely related to birthweight and may improve the antenatal identification of small‐for‐gestational‐age pregnancies.</description><subject>fetal monitoring</subject><subject>Gestational age</subject><subject>Growth disorders</subject><subject>Health risks</subject><subject>high‐risk pregnancy</subject><subject>Magnetic resonance imaging</subject><subject>Medical diagnosis</subject><subject>Placenta</subject><subject>placental transverse relaxation time</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>prenatal diagnosis</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kUlPwzAQhS0EgrJc-AHIEpeCFBgvcRJuCLFJbGI5W048oUFpArZL6b_HpcCBA3OZGel7T6N5hGwzOGCxDk3_7A-YhDRbIgOmABKQjC-TAQCwRAlZrJF171_ixjOZr5I1IXiaM1AD0t21psIumJYGZzr_js4jddiaDxOavqOhGSMdPvI9ij7OJqCl5Yxe318e0ZvejaPw3bQT9NR0loYR0qp3c_2XetqEES0bF0ZTbJ5HYZOs1Kb1uPXdN8jT2enjyUVydXt-eXJ8lVSiEFlSoUQoiixjea3QpJjXhbKZwFzUlnPBhTW1yqUFCyVyaQ1Kg8B5CpCWEsUGGS58X13_Fo8Letz4CtvWdNhPvOZSKRCpKPKI7v5BX_qJ6-J1mqdMMsUVm1P7C6pyvfcOa_3q4jfcTDPQ8xT0PAX9lUKEd74tJ-UY7S_68_YIsAUwbVqc_WOlj2_PHxamn77vkgQ</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Anderson, Kristi B.</creator><creator>Andersen, Anna S.</creator><creator>Hansen, Ditte N.</creator><creator>Sinding, Marianne</creator><creator>Peters, David A.</creator><creator>Frøkjær, Jens B.</creator><creator>Sørensen, Anne</creator><general>John Wiley & Sons, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1680-1879</orcidid><orcidid>https://orcid.org/0000-0002-0866-6654</orcidid></search><sort><creationdate>202105</creationdate><title>Placental transverse relaxation time (T2) estimated by MRI: Normal values and the correlation with birthweight</title><author>Anderson, Kristi B. ; Andersen, Anna S. ; Hansen, Ditte N. ; Sinding, Marianne ; Peters, David A. ; Frøkjær, Jens B. ; Sørensen, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3937-ce4e0997718f6ea5e8f96d73e83fd22323daf684d0d0be24dae4ae0225005b4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>fetal monitoring</topic><topic>Gestational age</topic><topic>Growth disorders</topic><topic>Health risks</topic><topic>high‐risk pregnancy</topic><topic>Magnetic resonance imaging</topic><topic>Medical diagnosis</topic><topic>Placenta</topic><topic>placental transverse relaxation time</topic><topic>Pregnancy</topic><topic>Prenatal development</topic><topic>prenatal diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Kristi B.</creatorcontrib><creatorcontrib>Andersen, Anna S.</creatorcontrib><creatorcontrib>Hansen, Ditte N.</creatorcontrib><creatorcontrib>Sinding, Marianne</creatorcontrib><creatorcontrib>Peters, David A.</creatorcontrib><creatorcontrib>Frøkjær, Jens B.</creatorcontrib><creatorcontrib>Sørensen, Anne</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Kristi B.</au><au>Andersen, Anna S.</au><au>Hansen, Ditte N.</au><au>Sinding, Marianne</au><au>Peters, David A.</au><au>Frøkjær, Jens B.</au><au>Sørensen, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental transverse relaxation time (T2) estimated by MRI: Normal values and the correlation with birthweight</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>2021-05</date><risdate>2021</risdate><volume>100</volume><issue>5</issue><spage>934</spage><epage>940</epage><pages>934-940</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><abstract>Introduction
Placental transverse relaxation time (T2) assessed by MRI may have the potential to improve the antenatal identification of small for gestational age. The aims of this study were to provide normal values of placental T2 in relation to gestational age at the time of MRI and to explore the correlation between placental T2 and birthweight.
Material and methods
A mixed cohort of 112 singleton pregnancies was retrieved from our placental MRI research database. MRI was performed at 23.6‐41.3 weeks of gestation in a 1.5T system (TE (8): 50‐440 ms, TR: 4000 ms). Normal pregnancies were defined by uncomplicated pregnancies with normal obstetric outcome and birthweight deviation within ±1 SD of the expected for gestational age. The correlation between placental T2 and birthweight was investigated using the following outcomes; small for gestational age (birthweight ≤−2 SD of the expected for gestational age) and birthweight deviation (birthweight Z‐scores).
Results
In normal pregnancies (n = 27), placenta T2 showed a significant negative linear correlation with gestational age (r = −.91, P = .0001) being 184 ms ± 15.94 ms (mean ± SD) at 20 weeks of gestation and 89 ms ± 15.94 ms at 40 weeks of gestation. Placental T2 was significantly reduced among small‐for‐gestational‐age pregnancies (mean Z‐score −1.95, P < .001). Moreover, we found a significant positive correlation between placenta T2 deviation (Z‐score) and birthweight deviation (Z‐score) (R2 = .26, P = .0001).
Conclusions
This study provides normal values of placental T2 to be used in future studies on placental MRI. Placental T2 is closely related to birthweight and may improve the antenatal identification of small‐for‐gestational‐age pregnancies.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>33258106</pmid><doi>10.1111/aogs.14057</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1680-1879</orcidid><orcidid>https://orcid.org/0000-0002-0866-6654</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | fetal monitoring Gestational age Growth disorders Health risks high‐risk pregnancy Magnetic resonance imaging Medical diagnosis Placenta placental transverse relaxation time Pregnancy Prenatal development prenatal diagnosis |
| title | Placental transverse relaxation time (T2) estimated by MRI: Normal values and the correlation with birthweight |
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