The utility of olfactory function in distinguishing early-stage Alzheimer's disease from HIV-associated neurocognitive disorders
Given the rising number of older people with HIV (PWH) and the overlap in cognitive dysfunction profiles in HIV-associated neurocognitive disorders (HAND) and Alzheimer's disease and its precursor, amnestic mild cognitive impairment (aMCI), methods are needed to distinguish aMCI/Alzheimer'...
Gespeichert in:
| Veröffentlicht in: | AIDS (London) 2021-03, Vol.35 (3), p.429-437 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 437 |
|---|---|
| container_issue | 3 |
| container_start_page | 429 |
| container_title | AIDS (London) |
| container_volume | 35 |
| creator | Sundermann, Erin E. Fields, Adam Saloner, Rowan Gouaux, Ben Bharti, Ajay Murphy, Claire Moore, David J. |
| description | Given the rising number of older people with HIV (PWH) and the overlap in cognitive dysfunction profiles in HIV-associated neurocognitive disorders (HAND) and Alzheimer's disease and its precursor, amnestic mild cognitive impairment (aMCI), methods are needed to distinguish aMCI/Alzheimer's disease from HAND. As an early indicator of Alzheimer's disease, we examined whether olfactory dysfunction could help to distinguish between aMCI/Alzheimer's disease and HAND among PWH.
An observational cohort study.
Eighty-one older (≥50 years) PWH (83% men, 65% white) from the California NeuroAIDS Tissue Consortium completed the University of Pennsylvania Smell Identification Test (UPSIT; higher scores = better smell identification) and a comprehensive seven-domain neuropsychological test battery and neuromedical evaluation. HAND was classified via Frascati criteria. High aMCI risk was defined as impairment (>1.0 SD below normative mean) on two of four delayed recall or recognition outcomes (at least one recognition impairment required) from the Hopkins Verbal Learning Test-Revised and the Brief Visuospatial Memory Test-Revised. We examined UPSIT scores in relation to aMCI risk and HAND status, and continuous memory scores considering adjustments for demographics and relevant clinical or HIV disease characteristics.
Fifty-seven participants were classified with HAND (70%) and 35 participants were classified as high aMCI risk (43%). UPSIT scores were lower (worse) in the high versus low aMCI risk group [F (1,76) = 10.04, P = 0.002], but did not differ by HAND status [F (1,76) = 0.62, P = 0.43]. UPSIT scores positively correlated with all memory outcomes (Ps |
| doi_str_mv | 10.1097/QAD.0000000000002761 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2465757376</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2465757376</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4649-7761dd92039216698316fd25d0db8050bc6069e6ae14ea0b650ef9a028bb136e3</originalsourceid><addsrcrecordid>eNpdkEtr3TAQhUVJaW7T_oNStEs2SvWwJWt5yRsCpZB2a2RrfK1WtlJJTrhZ5adHt0kfdDYHhm_OcA5CHxg9ZlSrT1_Wp8f0n-FKsldoxSolSF0rtodWlEtNtFB0H71N6XuBato0b9C-ELzmVSNW6PFmBLxk513e4jDg4AfT5xC3eFjmPrswYzdj61J282ZxaSyCwUS_JSmbDeC1fxjBTRAP0w4DkwAPMUz48uobMSmF3pkMFs-wxNCHzeyyu4MdGqKFmN6h14PxCd6_6AH6en52c3JJrj9fXJ2sr0lfyUoTVdJZqzkVmjMpdSOYHCyvLbVdU2J1vaRSgzTAKjC0kzWFQRvKm65jQoI4QEfPvrcx_Fwg5XZyqQfvzQxhSS2vZK1qJZQsaPWM9jGkFGFob6ObTNy2jLa77tvSfft_9-Xs48uHpZvA_jn6XfZf3_vgc4n-wy_3ENsRjM_jL78SjxJOOSvKKNmttHgC3rSQiA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2465757376</pqid></control><display><type>article</type><title>The utility of olfactory function in distinguishing early-stage Alzheimer's disease from HIV-associated neurocognitive disorders</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Sundermann, Erin E. ; Fields, Adam ; Saloner, Rowan ; Gouaux, Ben ; Bharti, Ajay ; Murphy, Claire ; Moore, David J.</creator><creatorcontrib>Sundermann, Erin E. ; Fields, Adam ; Saloner, Rowan ; Gouaux, Ben ; Bharti, Ajay ; Murphy, Claire ; Moore, David J.</creatorcontrib><description>Given the rising number of older people with HIV (PWH) and the overlap in cognitive dysfunction profiles in HIV-associated neurocognitive disorders (HAND) and Alzheimer's disease and its precursor, amnestic mild cognitive impairment (aMCI), methods are needed to distinguish aMCI/Alzheimer's disease from HAND. As an early indicator of Alzheimer's disease, we examined whether olfactory dysfunction could help to distinguish between aMCI/Alzheimer's disease and HAND among PWH.
An observational cohort study.
Eighty-one older (≥50 years) PWH (83% men, 65% white) from the California NeuroAIDS Tissue Consortium completed the University of Pennsylvania Smell Identification Test (UPSIT; higher scores = better smell identification) and a comprehensive seven-domain neuropsychological test battery and neuromedical evaluation. HAND was classified via Frascati criteria. High aMCI risk was defined as impairment (>1.0 SD below normative mean) on two of four delayed recall or recognition outcomes (at least one recognition impairment required) from the Hopkins Verbal Learning Test-Revised and the Brief Visuospatial Memory Test-Revised. We examined UPSIT scores in relation to aMCI risk and HAND status, and continuous memory scores considering adjustments for demographics and relevant clinical or HIV disease characteristics.
Fifty-seven participants were classified with HAND (70%) and 35 participants were classified as high aMCI risk (43%). UPSIT scores were lower (worse) in the high versus low aMCI risk group [F (1,76) = 10.04, P = 0.002], but did not differ by HAND status [F (1,76) = 0.62, P = 0.43]. UPSIT scores positively correlated with all memory outcomes (Ps < 0.05).
Olfactory assessments may help in detecting early aMCI/Alzheimer's disease among PWH and allow for appropriate and early disease intervention.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000002761</identifier><identifier>PMID: 33252483</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - complications ; Alzheimer Disease - diagnosis ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - etiology ; Female ; HIV Infections - complications ; Humans ; Male ; Memory ; Neuropsychological Tests</subject><ispartof>AIDS (London), 2021-03, Vol.35 (3), p.429-437</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4649-7761dd92039216698316fd25d0db8050bc6069e6ae14ea0b650ef9a028bb136e3</citedby><cites>FETCH-LOGICAL-c4649-7761dd92039216698316fd25d0db8050bc6069e6ae14ea0b650ef9a028bb136e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33252483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sundermann, Erin E.</creatorcontrib><creatorcontrib>Fields, Adam</creatorcontrib><creatorcontrib>Saloner, Rowan</creatorcontrib><creatorcontrib>Gouaux, Ben</creatorcontrib><creatorcontrib>Bharti, Ajay</creatorcontrib><creatorcontrib>Murphy, Claire</creatorcontrib><creatorcontrib>Moore, David J.</creatorcontrib><title>The utility of olfactory function in distinguishing early-stage Alzheimer's disease from HIV-associated neurocognitive disorders</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>Given the rising number of older people with HIV (PWH) and the overlap in cognitive dysfunction profiles in HIV-associated neurocognitive disorders (HAND) and Alzheimer's disease and its precursor, amnestic mild cognitive impairment (aMCI), methods are needed to distinguish aMCI/Alzheimer's disease from HAND. As an early indicator of Alzheimer's disease, we examined whether olfactory dysfunction could help to distinguish between aMCI/Alzheimer's disease and HAND among PWH.
An observational cohort study.
Eighty-one older (≥50 years) PWH (83% men, 65% white) from the California NeuroAIDS Tissue Consortium completed the University of Pennsylvania Smell Identification Test (UPSIT; higher scores = better smell identification) and a comprehensive seven-domain neuropsychological test battery and neuromedical evaluation. HAND was classified via Frascati criteria. High aMCI risk was defined as impairment (>1.0 SD below normative mean) on two of four delayed recall or recognition outcomes (at least one recognition impairment required) from the Hopkins Verbal Learning Test-Revised and the Brief Visuospatial Memory Test-Revised. We examined UPSIT scores in relation to aMCI risk and HAND status, and continuous memory scores considering adjustments for demographics and relevant clinical or HIV disease characteristics.
Fifty-seven participants were classified with HAND (70%) and 35 participants were classified as high aMCI risk (43%). UPSIT scores were lower (worse) in the high versus low aMCI risk group [F (1,76) = 10.04, P = 0.002], but did not differ by HAND status [F (1,76) = 0.62, P = 0.43]. UPSIT scores positively correlated with all memory outcomes (Ps < 0.05).
Olfactory assessments may help in detecting early aMCI/Alzheimer's disease among PWH and allow for appropriate and early disease intervention.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>Humans</subject><subject>Male</subject><subject>Memory</subject><subject>Neuropsychological Tests</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtr3TAQhUVJaW7T_oNStEs2SvWwJWt5yRsCpZB2a2RrfK1WtlJJTrhZ5adHt0kfdDYHhm_OcA5CHxg9ZlSrT1_Wp8f0n-FKsldoxSolSF0rtodWlEtNtFB0H71N6XuBato0b9C-ELzmVSNW6PFmBLxk513e4jDg4AfT5xC3eFjmPrswYzdj61J282ZxaSyCwUS_JSmbDeC1fxjBTRAP0w4DkwAPMUz48uobMSmF3pkMFs-wxNCHzeyyu4MdGqKFmN6h14PxCd6_6AH6en52c3JJrj9fXJ2sr0lfyUoTVdJZqzkVmjMpdSOYHCyvLbVdU2J1vaRSgzTAKjC0kzWFQRvKm65jQoI4QEfPvrcx_Fwg5XZyqQfvzQxhSS2vZK1qJZQsaPWM9jGkFGFob6ObTNy2jLa77tvSfft_9-Xs48uHpZvA_jn6XfZf3_vgc4n-wy_3ENsRjM_jL78SjxJOOSvKKNmttHgC3rSQiA</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Sundermann, Erin E.</creator><creator>Fields, Adam</creator><creator>Saloner, Rowan</creator><creator>Gouaux, Ben</creator><creator>Bharti, Ajay</creator><creator>Murphy, Claire</creator><creator>Moore, David J.</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>The utility of olfactory function in distinguishing early-stage Alzheimer's disease from HIV-associated neurocognitive disorders</title><author>Sundermann, Erin E. ; Fields, Adam ; Saloner, Rowan ; Gouaux, Ben ; Bharti, Ajay ; Murphy, Claire ; Moore, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4649-7761dd92039216698316fd25d0db8050bc6069e6ae14ea0b650ef9a028bb136e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>Humans</topic><topic>Male</topic><topic>Memory</topic><topic>Neuropsychological Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sundermann, Erin E.</creatorcontrib><creatorcontrib>Fields, Adam</creatorcontrib><creatorcontrib>Saloner, Rowan</creatorcontrib><creatorcontrib>Gouaux, Ben</creatorcontrib><creatorcontrib>Bharti, Ajay</creatorcontrib><creatorcontrib>Murphy, Claire</creatorcontrib><creatorcontrib>Moore, David J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sundermann, Erin E.</au><au>Fields, Adam</au><au>Saloner, Rowan</au><au>Gouaux, Ben</au><au>Bharti, Ajay</au><au>Murphy, Claire</au><au>Moore, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The utility of olfactory function in distinguishing early-stage Alzheimer's disease from HIV-associated neurocognitive disorders</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>35</volume><issue>3</issue><spage>429</spage><epage>437</epage><pages>429-437</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>Given the rising number of older people with HIV (PWH) and the overlap in cognitive dysfunction profiles in HIV-associated neurocognitive disorders (HAND) and Alzheimer's disease and its precursor, amnestic mild cognitive impairment (aMCI), methods are needed to distinguish aMCI/Alzheimer's disease from HAND. As an early indicator of Alzheimer's disease, we examined whether olfactory dysfunction could help to distinguish between aMCI/Alzheimer's disease and HAND among PWH.
An observational cohort study.
Eighty-one older (≥50 years) PWH (83% men, 65% white) from the California NeuroAIDS Tissue Consortium completed the University of Pennsylvania Smell Identification Test (UPSIT; higher scores = better smell identification) and a comprehensive seven-domain neuropsychological test battery and neuromedical evaluation. HAND was classified via Frascati criteria. High aMCI risk was defined as impairment (>1.0 SD below normative mean) on two of four delayed recall or recognition outcomes (at least one recognition impairment required) from the Hopkins Verbal Learning Test-Revised and the Brief Visuospatial Memory Test-Revised. We examined UPSIT scores in relation to aMCI risk and HAND status, and continuous memory scores considering adjustments for demographics and relevant clinical or HIV disease characteristics.
Fifty-seven participants were classified with HAND (70%) and 35 participants were classified as high aMCI risk (43%). UPSIT scores were lower (worse) in the high versus low aMCI risk group [F (1,76) = 10.04, P = 0.002], but did not differ by HAND status [F (1,76) = 0.62, P = 0.43]. UPSIT scores positively correlated with all memory outcomes (Ps < 0.05).
Olfactory assessments may help in detecting early aMCI/Alzheimer's disease among PWH and allow for appropriate and early disease intervention.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33252483</pmid><doi>10.1097/QAD.0000000000002761</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2021-03, Vol.35 (3), p.429-437 |
| issn | 0269-9370 1473-5571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2465757376 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - diagnosis Cognitive Dysfunction - diagnosis Cognitive Dysfunction - etiology Female HIV Infections - complications Humans Male Memory Neuropsychological Tests |
| title | The utility of olfactory function in distinguishing early-stage Alzheimer's disease from HIV-associated neurocognitive disorders |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T15%3A59%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20utility%20of%20olfactory%20function%20in%20distinguishing%20early-stage%20Alzheimer's%20disease%20from%20HIV-associated%20neurocognitive%20disorders&rft.jtitle=AIDS%20(London)&rft.au=Sundermann,%20Erin%20E.&rft.date=2021-03-01&rft.volume=35&rft.issue=3&rft.spage=429&rft.epage=437&rft.pages=429-437&rft.issn=0269-9370&rft.eissn=1473-5571&rft_id=info:doi/10.1097/QAD.0000000000002761&rft_dat=%3Cproquest_cross%3E2465757376%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2465757376&rft_id=info:pmid/33252483&rfr_iscdi=true |