Oxidized low‐density lipoprotein accelerates the injury of endothelial cells via circ‐USP36/miR‐98‐5p/VCAM1 axis

Circular RNAs (circRNAs) are a group of RNAs featured by a covalently closed continuous loop structure. This study aimed to uncover the function and mechanism of circ‐ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low‐density lipoprotein (ox‐LDL). The levels of ci...

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Veröffentlicht in:	IUBMB life 2021-01, Vol.73 (1), p.177-187
Hauptverfasser:	Peng, Kuang, Jiang, Peiyong, Du, Yafang, Zeng, Dianmei, Zhao, Junbi, Li, Meiling, Xia, Chunchen, Xie, Zhong, Wu, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis atherosclerosis Cell adhesion & migration Cell adhesion molecules Cell Proliferation circ‐USP36 Endothelial cells Endothelium, Vascular - drug effects Endothelium, Vascular - injuries Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzyme-linked immunosorbent assay Flow cytometry Gene Expression Regulation Human Umbilical Vein Endothelial Cells Humans Immunoprecipitation Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - pathology Lipoproteins, LDL - adverse effects Low density lipoprotein MicroRNAs - genetics miRNA miR‐98‐5p ox‐LDL Peptidase Polymerase chain reaction RNA, Circular - genetics Signal Transduction Transfection Ubiquitin Ubiquitin Thiolesterase - genetics Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism VCAM1 Viability
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