Clostridium difficile toxin A and toxin B inhibit YAP in the colonic epithelial cells

Toxin A (TcdA) and toxin B (TcdB), the two exotoxins of Clostridium difficile, are main causal agents for the colonic epithelium damage in Clostridium difficile infection (CDI). The Hippo pathway is crucial for the control of tissue homeostasis and regeneration of intestines. However, the dysregulat...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2021-02, Vol.35 (2), p.e22652-n/a
Hauptverfasser:	Song, Jinglue, Shen, Xia, Huang, Zhenyu, Liu, Yun, Cui, Long, Cui, Xuewei, Liu, Chen‐Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell proliferation Clostridium difficile Cytoplasm Cytoskeleton Epithelial cells Epithelium Exotoxins Homeostasis Intestine mRNA Pathogenesis Regeneration Rounding TAZ Toxin A Toxin B Toxins Transcription YAP Yes-associated protein
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