mTORC1‐mediated amino acid signaling is critical for cell fate determination under transplant‐induced stress

Transplantation of in vitro‐manipulated cells is widely used in hematology. While transplantation is well recognized to impose severe stress on transplanted cells, the nature of transplant‐induced stress remains elusive. Here, we propose that the lack of amino acids in serum is the major cause of tr...

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Veröffentlicht in:	FEBS letters 2021-02, Vol.595 (4), p.462-475
Hauptverfasser:	Cheng, Xiaoyan, Ge, Maolin, Zhu, Shouhai, Li, Dan, Wang, Ruiheng, Xu, Qiongyu, Chen, Zhihong, Xie, Shufeng, Liu, Han
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid leukemia metabolism mTORC1 transplant‐induced stress
Online-Zugang:	Volltext
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