Effect of 10-Valent Pneumococcal Conjugate Vaccine on Streptococcus pneumoniae Nasopharyngeal Carriage Among Children Less Than 5 Years Old: 3 Years Post-10-Valent Pneumococcal Conjugate Vaccine Introduction in Mozambique
Mozambique introduced 10-valent pneumococcal conjugate vaccine (PCV10) in 2013 with doses at ages 2, 3, and 4 months and no catch-up or booster dose. We evaluated PCV10 impact on the carriage of vaccine-type (VT), non-VT, and antimicrobial non-susceptible pneumococci 3 years after introduction. We c...
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| Veröffentlicht in: | Journal of the Pediatric Infectious Diseases Society 2021-04, Vol.10 (4), p.448-456 |
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| creator | Valenciano, Sandra J Moiane, Benild Lessa, Fernanda C Chaúque, Alberto Massora, Sergio Pimenta, Fabiana C Mucavele, Helio Verani, Jennifer R da Gloria Carvalho, Maria Whitney, Cynthia G Tembe, Nelson Sigaúque, Betuel |
| description | Mozambique introduced 10-valent pneumococcal conjugate vaccine (PCV10) in 2013 with doses at ages 2, 3, and 4 months and no catch-up or booster dose. We evaluated PCV10 impact on the carriage of vaccine-type (VT), non-VT, and antimicrobial non-susceptible pneumococci 3 years after introduction.
We conducted cross-sectional carriage surveys among HIV-infected and HIV-uninfected children aged 6 weeks to 59 months: 1 pre-PCV10 (2012-2013 [Baseline]) and 2 post-PCV10 introductions (2014-2015 [Post1] and 2015-2016 [Post2]). Pneumococci isolated from nasopharyngeal swabs underwent Quellung serotyping and antimicrobial susceptibility testing. Non-susceptible isolates (intermediate or resistant) were defined using Clinical and Laboratory Standards Institute 2018 breakpoints. We used log-binomial regression to estimate changes in the pneumococcal carriage between survey periods. We compared proportions of non-susceptible pneumococci between Baseline and Post2.
We enrolled 720 children at Baseline, 911 at Post1, and 1208 at Post2. Baseline VT carriage was similar for HIV-uninfected (36.0%, 110/306) and HIV-infected children (34.8%, 144/414). VT carriage was 36% (95% confidence interval [CI]: 19%-49%) and 27% (95% CI: 11%-41%) lower in Post1 vs baseline among HIV-uninfected and HIV-infected children, respectively. VT carriage prevalence declined in Post2 vs Post1 for HIV-uninfected but remained stable for HIV-infected children. VT carriage prevalence 3 years after PCV10 introduction was 14.5% in HIV-uninfected and 21.0% in HIV-infected children. Pneumococcal isolates non-susceptible to penicillin declined from 66.0% to 56.2% (P= .0281) among HIV-infected children.
VT and antimicrobial non-susceptible pneumococci carriage dropped after PCV10 introduction, especially in HIV-uninfected children. However, VT carriage remained common, indicating ongoing VT pneumococci transmission. |
| doi_str_mv | 10.1093/jpids/piaa132 |
| format | Article |
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We conducted cross-sectional carriage surveys among HIV-infected and HIV-uninfected children aged 6 weeks to 59 months: 1 pre-PCV10 (2012-2013 [Baseline]) and 2 post-PCV10 introductions (2014-2015 [Post1] and 2015-2016 [Post2]). Pneumococci isolated from nasopharyngeal swabs underwent Quellung serotyping and antimicrobial susceptibility testing. Non-susceptible isolates (intermediate or resistant) were defined using Clinical and Laboratory Standards Institute 2018 breakpoints. We used log-binomial regression to estimate changes in the pneumococcal carriage between survey periods. We compared proportions of non-susceptible pneumococci between Baseline and Post2.
We enrolled 720 children at Baseline, 911 at Post1, and 1208 at Post2. Baseline VT carriage was similar for HIV-uninfected (36.0%, 110/306) and HIV-infected children (34.8%, 144/414). VT carriage was 36% (95% confidence interval [CI]: 19%-49%) and 27% (95% CI: 11%-41%) lower in Post1 vs baseline among HIV-uninfected and HIV-infected children, respectively. VT carriage prevalence declined in Post2 vs Post1 for HIV-uninfected but remained stable for HIV-infected children. VT carriage prevalence 3 years after PCV10 introduction was 14.5% in HIV-uninfected and 21.0% in HIV-infected children. Pneumococcal isolates non-susceptible to penicillin declined from 66.0% to 56.2% (P= .0281) among HIV-infected children.
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We conducted cross-sectional carriage surveys among HIV-infected and HIV-uninfected children aged 6 weeks to 59 months: 1 pre-PCV10 (2012-2013 [Baseline]) and 2 post-PCV10 introductions (2014-2015 [Post1] and 2015-2016 [Post2]). Pneumococci isolated from nasopharyngeal swabs underwent Quellung serotyping and antimicrobial susceptibility testing. Non-susceptible isolates (intermediate or resistant) were defined using Clinical and Laboratory Standards Institute 2018 breakpoints. We used log-binomial regression to estimate changes in the pneumococcal carriage between survey periods. We compared proportions of non-susceptible pneumococci between Baseline and Post2.
We enrolled 720 children at Baseline, 911 at Post1, and 1208 at Post2. Baseline VT carriage was similar for HIV-uninfected (36.0%, 110/306) and HIV-infected children (34.8%, 144/414). VT carriage was 36% (95% confidence interval [CI]: 19%-49%) and 27% (95% CI: 11%-41%) lower in Post1 vs baseline among HIV-uninfected and HIV-infected children, respectively. VT carriage prevalence declined in Post2 vs Post1 for HIV-uninfected but remained stable for HIV-infected children. VT carriage prevalence 3 years after PCV10 introduction was 14.5% in HIV-uninfected and 21.0% in HIV-infected children. Pneumococcal isolates non-susceptible to penicillin declined from 66.0% to 56.2% (P= .0281) among HIV-infected children.
VT and antimicrobial non-susceptible pneumococci carriage dropped after PCV10 introduction, especially in HIV-uninfected children. However, VT carriage remained common, indicating ongoing VT pneumococci transmission.</description><issn>2048-7207</issn><issn>2048-7207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkU1v1EAMhkcIRKvSI1fkI5fQ-Uyy3KpVC5UWWolSiVPkTJzdWSUzYWZygP_KfyHdLogjvtiWH3_IL2OvBX8n-Epd7CfXpYvJIQoln7FTyXVdVJJXz_-JT9h5Snu-WGmEqfVLdqKU1EZIfcp-XfU92QyhB8GLBxzIZ7jzNI_BBmtxgHXw-3mLmeABrXWeIHj4kiNN-YDMCaYD7x0SfMYUph3GH35Lj80Yo8MtweVS38J654YukocNpQT3O_Rg4BthTHA7dO9BHZO7kHLx3_fc-BxDN9vslsuch0_hJ46t-z7TK_aixyHR-dGfsa_XV_frj8Xm9sPN-nJT2OUTudCy7erSlJxL3rXc1qWsO2Nk30pRa8NXNUq1Qt6uStWiQNNqWbVSa6o0x0qpM_b2ae4Uw7I25WZ0ydIwoKcwp0bq0mhd6QNaPKE2hpQi9c0U3bg8rBG8eRS1OYjaHEVd-DfH0XM7UveX_iOh-g2Yt6FO</recordid><startdate>20210430</startdate><enddate>20210430</enddate><creator>Valenciano, Sandra J</creator><creator>Moiane, Benild</creator><creator>Lessa, Fernanda C</creator><creator>Chaúque, Alberto</creator><creator>Massora, Sergio</creator><creator>Pimenta, Fabiana C</creator><creator>Mucavele, Helio</creator><creator>Verani, Jennifer R</creator><creator>da Gloria Carvalho, Maria</creator><creator>Whitney, Cynthia G</creator><creator>Tembe, Nelson</creator><creator>Sigaúque, Betuel</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210430</creationdate><title>Effect of 10-Valent Pneumococcal Conjugate Vaccine on Streptococcus pneumoniae Nasopharyngeal Carriage Among Children Less Than 5 Years Old: 3 Years Post-10-Valent Pneumococcal Conjugate Vaccine Introduction in Mozambique</title><author>Valenciano, Sandra J ; Moiane, Benild ; Lessa, Fernanda C ; Chaúque, Alberto ; Massora, Sergio ; Pimenta, Fabiana C ; Mucavele, Helio ; Verani, Jennifer R ; da Gloria Carvalho, Maria ; Whitney, Cynthia G ; Tembe, Nelson ; Sigaúque, Betuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-42bd86560020db0c8628d552fb21845098a239a0b963ba1a5b427b244e740a733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Valenciano, Sandra J</creatorcontrib><creatorcontrib>Moiane, Benild</creatorcontrib><creatorcontrib>Lessa, Fernanda C</creatorcontrib><creatorcontrib>Chaúque, Alberto</creatorcontrib><creatorcontrib>Massora, Sergio</creatorcontrib><creatorcontrib>Pimenta, Fabiana C</creatorcontrib><creatorcontrib>Mucavele, Helio</creatorcontrib><creatorcontrib>Verani, Jennifer R</creatorcontrib><creatorcontrib>da Gloria Carvalho, Maria</creatorcontrib><creatorcontrib>Whitney, Cynthia G</creatorcontrib><creatorcontrib>Tembe, Nelson</creatorcontrib><creatorcontrib>Sigaúque, Betuel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pediatric Infectious Diseases Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valenciano, Sandra J</au><au>Moiane, Benild</au><au>Lessa, Fernanda C</au><au>Chaúque, Alberto</au><au>Massora, Sergio</au><au>Pimenta, Fabiana C</au><au>Mucavele, Helio</au><au>Verani, Jennifer R</au><au>da Gloria Carvalho, Maria</au><au>Whitney, Cynthia G</au><au>Tembe, Nelson</au><au>Sigaúque, Betuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of 10-Valent Pneumococcal Conjugate Vaccine on Streptococcus pneumoniae Nasopharyngeal Carriage Among Children Less Than 5 Years Old: 3 Years Post-10-Valent Pneumococcal Conjugate Vaccine Introduction in Mozambique</atitle><jtitle>Journal of the Pediatric Infectious Diseases Society</jtitle><addtitle>J Pediatric Infect Dis Soc</addtitle><date>2021-04-30</date><risdate>2021</risdate><volume>10</volume><issue>4</issue><spage>448</spage><epage>456</epage><pages>448-456</pages><issn>2048-7207</issn><eissn>2048-7207</eissn><abstract>Mozambique introduced 10-valent pneumococcal conjugate vaccine (PCV10) in 2013 with doses at ages 2, 3, and 4 months and no catch-up or booster dose. We evaluated PCV10 impact on the carriage of vaccine-type (VT), non-VT, and antimicrobial non-susceptible pneumococci 3 years after introduction.
We conducted cross-sectional carriage surveys among HIV-infected and HIV-uninfected children aged 6 weeks to 59 months: 1 pre-PCV10 (2012-2013 [Baseline]) and 2 post-PCV10 introductions (2014-2015 [Post1] and 2015-2016 [Post2]). Pneumococci isolated from nasopharyngeal swabs underwent Quellung serotyping and antimicrobial susceptibility testing. Non-susceptible isolates (intermediate or resistant) were defined using Clinical and Laboratory Standards Institute 2018 breakpoints. We used log-binomial regression to estimate changes in the pneumococcal carriage between survey periods. We compared proportions of non-susceptible pneumococci between Baseline and Post2.
We enrolled 720 children at Baseline, 911 at Post1, and 1208 at Post2. Baseline VT carriage was similar for HIV-uninfected (36.0%, 110/306) and HIV-infected children (34.8%, 144/414). VT carriage was 36% (95% confidence interval [CI]: 19%-49%) and 27% (95% CI: 11%-41%) lower in Post1 vs baseline among HIV-uninfected and HIV-infected children, respectively. VT carriage prevalence declined in Post2 vs Post1 for HIV-uninfected but remained stable for HIV-infected children. VT carriage prevalence 3 years after PCV10 introduction was 14.5% in HIV-uninfected and 21.0% in HIV-infected children. Pneumococcal isolates non-susceptible to penicillin declined from 66.0% to 56.2% (P= .0281) among HIV-infected children.
VT and antimicrobial non-susceptible pneumococci carriage dropped after PCV10 introduction, especially in HIV-uninfected children. However, VT carriage remained common, indicating ongoing VT pneumococci transmission.</abstract><cop>England</cop><pmid>33245124</pmid><doi>10.1093/jpids/piaa132</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| title | Effect of 10-Valent Pneumococcal Conjugate Vaccine on Streptococcus pneumoniae Nasopharyngeal Carriage Among Children Less Than 5 Years Old: 3 Years Post-10-Valent Pneumococcal Conjugate Vaccine Introduction in Mozambique |
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