Regiospecific Synthesis of Calcium‐Independent Daptomycin Antibiotics using a Chemoenzymatic Method

Daptomycin (DAP) is a calcium (Ca2+)‐dependent FDA‐approved antibiotic drug for the treatment of Gram‐positive infections. It possesses a complex pharmacophore hampering derivatization and/or synthesis of analogues. To mimic the Ca2+‐binding effect, we used a chemoenzymatic approach to modify the tr...

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Veröffentlicht in:	Chemistry : a European journal 2021-02, Vol.27 (12), p.4176-4182
Hauptverfasser:	Mupparapu, Nagaraju, Lin, Yu‐Hsin Cindy, Kim, Tae Ho, Elshahawi, Sherif I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics biological activity Calcium Calcium ions Chemistry Daptomycin enzymes Gram-Positive Bacteria Microbial Sensitivity Tests natural products reaction mechanisms Synthesis Tryptophan
Online-Zugang:	Volltext
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