The alkaloid, soyauxinium chloride, displays remarkable cytotoxic effects towards a panel of cancer cells, inducing apoptosis, ferroptosis and necroptosis

The cytotoxic potential of a naturally occurring indoloquinazoline alkaloid, soyauxinium chloride (SCHL), was determined on a broad panel of animal and human cancer cell lines, including various sensitive and drug-resistant phenotypes. The cytotoxicity, SCHL-induced autophagic, ferroptotic, and necr...

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Veröffentlicht in:	Chemico-biological interactions 2021-01, Vol.333, p.109334-109334, Article 109334
Hauptverfasser:	Mbaveng, Armelle T., Noulala, Cédric G.T., Samba, Anne R.M., Tankeo, Simplice B., Abdelfatah, Sara, Fotso, Ghislain W., Happi, Emmanuel N., Ngadjui, Bonaventure T., Beng, Veronique P., Kuete, Victor, Efferth, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Cancer Cell Cycle - drug effects Cell death Cell Line, Tumor Ferroptosis - drug effects Humans Indoloquinazoline Mitochondrial Membranes - drug effects Mitochondrial Membranes - pathology Multidrug resistance Natural product Necroptosis - drug effects Reactive Oxygen Species - metabolism Regulated Cell Death - drug effects
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