Crystal Structure and Pathophysiological Role of the Pneumococcal Nucleoside-binding Protein PnrA

[Display omitted] •De novo synthesis but also uptake of nucleosides is essential for bacterial cell viability.•Lipoprotein PnrA is the only known pneumococcal substrate binding protein for nucleosides.•The 3-D structure of PnrA is deciphered in complex with five nucleosides.•PnrA plasticity is essen...

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Veröffentlicht in:	Journal of molecular biology 2021-01, Vol.433 (2), p.166723-166723, Article 166723
Hauptverfasser:	Abdullah, Mohammed R., Batuecas, María T., Jennert, Franziska, Voß, Franziska, Westhoff, Philipp, Kohler, Thomas P., Molina, Rafael, Hirschmann, Stephanie, Lalk, Michael, Hermoso, Juan A., Hammerschmidt, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism crystal structure Crystallography, X-Ray Disease Models, Animal Humans Hydrogen Bonding Kinetics Macrophages - immunology Macrophages - metabolism Mice Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation nucleoside Nucleosides - chemistry Nucleosides - metabolism Phagocytosis physiology pneumococci Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - metabolism Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - pathology Protein Binding Protein Conformation Streptococcus pneumoniae - immunology Streptococcus pneumoniae - metabolism Structure-Activity Relationship transporter virulence
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