Axl and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Antitumor Immunity

Despite the promising clinical benefit of targeted and immune checkpoint blocking therapeutics, current strategies have limited success in breast cancer, indicating that additional inhibitory pathways are required to complement existing therapeutics. TAM receptors (Tyro-3, Axl, and Mertk) are often...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-02, Vol.81 (3), p.698-712
Hauptverfasser:	Davra, Viralkumar, Kumar, Sushil, Geng, Ke, Calianese, David, Mehta, Dhriti, Gadiyar, Varsha, Kasikara, Canan, Lahey, Kevin C, Chang, Yun-Juan, Wichroski, Michael, Gao, Chan, De Lorenzo, Mariana S, Kotenko, Sergei V, Bergsbaken, Tessa, Mishra, Pankaj K, Gause, William C, Quigley, Michael, Spires, Thomas E, Birge, Raymond B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axl Receptor Tyrosine Kinase c-Mer Tyrosine Kinase - genetics c-Mer Tyrosine Kinase - immunology c-Mer Tyrosine Kinase - metabolism Cell Line, Tumor Cells, Cultured Female Gene Expression Regulation, Neoplastic - immunology Humans Immune Evasion - genetics Immune Evasion - immunology Immunotherapy - methods Kaplan-Meier Estimate Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - therapy Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, SCID Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology Proto-Oncogene Proteins - metabolism Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - immunology Receptor Protein-Tyrosine Kinases - metabolism Signal Transduction - genetics Signal Transduction - immunology
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