Development of a conventional immunochemical detection system for determination of Nδ-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine in methylglyoxal-modified proteins

Methylglyoxal (MGO) produced during glycolysis is known to react with arginine residues on proteins to generate advanced glycation end products, such as N δ -(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine (MG-H1). Since the production of MGO is increased during hyperglycemia or metabolic disorders...

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Veröffentlicht in:	Glycoconjugate journal 2021-06, Vol.38 (3), p.293-301
Hauptverfasser:	Yamaguchi, Hiroko, Nagai, Mime, Sugawa, Hikari, Yasuda, Hisataka, Nagai, Ryoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end products Advances in Glcation: from food to human health and disease Amino acids Antibodies Biochemistry Biomedical and Life Sciences Carbohydrate metabolism Enzyme-linked immunosorbent assay Glycolysis Glycosylation Hyperglycemia Imidazoles - chemistry Immunochemistry Ions Life Sciences Liquid chromatography Mass spectroscopy Metabolic disorders Monoclonal antibodies Oligopeptides - chemistry Original Article Ornithine Ornithine - analogs & derivatives Ornithine - chemistry Pathology Proteins Pyruvaldehyde Pyruvaldehyde - chemistry Western blotting
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