Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet

[Display omitted] •Morin increases HDL and decreases LDL and blood pressure.•PUFAs decrease glucose and cholesterol.•Morin and PUFAs decrease the RNAm expression of Nlrp3 and Tnf-α.•Morin modulates the transcript of Casp-1, Il-1β and Il-, Pparγ, Pparα and Adiponectin.•The mixture maintained the mRNA expression levels of Tlr4 and Ucp2. Morin and PUFAs are bioactive compounds provided by the diet, with multiple biological activities, among which are the modulation of inflammation in various chronic diseases. The effect of supplementation with Morin, PUFAs, and the mixture of both on the levels of mRNA expression of the Nlrp3 inflammasome as well as genes associated with inflammation and lipid metabolism, in an obesity model through a high-fat diet, during 8 weeks of administration were evaluated. The three treatments negatively regulated the expression of Nlrp3 mRNA. Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.