Adhesion barriers in laparoscopic myomectomy: Evidence from randomized clinical trials
Objective To evaluate the effectiveness of different adhesion barriers in the prevention of de novo adhesion development after laparoscopic myomectomy. Methods A systematic review was performed by searching seven electronic databases for all randomized clinical trials (RCTs) comparing the use of any...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2021-03, Vol.152 (3), p.308-320 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Borghese, Giulia Raffone, Antonio Raimondo, Diego Saccone, Gabriele Travaglino, Antonio Degli Esposti, Eugenia Mastronardi, Manuela Salucci, Paolo Zullo, Fulvio Seracchioli, Renato |
| description | Objective
To evaluate the effectiveness of different adhesion barriers in the prevention of de novo adhesion development after laparoscopic myomectomy.
Methods
A systematic review was performed by searching seven electronic databases for all randomized clinical trials (RCTs) comparing the use of any absorbable adhesion barrier (i.e. intervention group) with either no treatment or placebo (i.e. control group) in the prevention of adhesion development after laparoscopic myomectomy.
Results
Eight RCTs with a total of 748 participants (392 in the intervention group and 356 in the control group) were included. The assessed adhesion barrier methods were: oxidized regenerated cellulose (ORC) in two studies, auto‐crosslinked hyaluronic acid (HA) gel in two studies, 4% icodextrin solution in one study, modified HA and carboxy‐methylcellulose in one study, polyethylene glycol ester trilysine amine solution plus a borate buffer solution in one study, and polyethylene glycol amine plus dextran aldehyde polymers in another study.
Conclusion
Adhesion barrier methods showing the most promising results were: ORC, auto‐crosslinked HA gel, and polyethylene glycol amine plus dextran aldehyde polymers.
Synopsis
Most promising adhesion barriers after laparoscopic myomectomy are oxidized regenerated cellulose, auto‐crosslinked hyaluronic acid gel, and polyethylene glycol amine plus dextran aldehyde polymers. |
| doi_str_mv | 10.1002/ijgo.13495 |
| format | Article |
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To evaluate the effectiveness of different adhesion barriers in the prevention of de novo adhesion development after laparoscopic myomectomy.
Methods
A systematic review was performed by searching seven electronic databases for all randomized clinical trials (RCTs) comparing the use of any absorbable adhesion barrier (i.e. intervention group) with either no treatment or placebo (i.e. control group) in the prevention of adhesion development after laparoscopic myomectomy.
Results
Eight RCTs with a total of 748 participants (392 in the intervention group and 356 in the control group) were included. The assessed adhesion barrier methods were: oxidized regenerated cellulose (ORC) in two studies, auto‐crosslinked hyaluronic acid (HA) gel in two studies, 4% icodextrin solution in one study, modified HA and carboxy‐methylcellulose in one study, polyethylene glycol ester trilysine amine solution plus a borate buffer solution in one study, and polyethylene glycol amine plus dextran aldehyde polymers in another study.
Conclusion
Adhesion barrier methods showing the most promising results were: ORC, auto‐crosslinked HA gel, and polyethylene glycol amine plus dextran aldehyde polymers.
Synopsis
Most promising adhesion barriers after laparoscopic myomectomy are oxidized regenerated cellulose, auto‐crosslinked hyaluronic acid gel, and polyethylene glycol amine plus dextran aldehyde polymers.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.13495</identifier><identifier>PMID: 33237574</identifier><language>eng</language><publisher>United States</publisher><subject>Cellulose, Oxidized - administration & dosage ; Databases, Factual ; Device ; Female ; Fibroid ; Gynecology ; Humans ; Laparoscopy ; Laparoscopy - adverse effects ; Myoma ; Prevention ; Randomized Controlled Trials as Topic ; Surgery ; Tissue Adhesions - etiology ; Tissue Adhesions - prevention & control ; Uterine Myomectomy - adverse effects ; Uterus</subject><ispartof>International journal of gynecology and obstetrics, 2021-03, Vol.152 (3), p.308-320</ispartof><rights>2020 International Federation of Gynecology and Obstetrics</rights><rights>2020 International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3955-2429c8ffcad9799bdac4271b7c46bf1663440a6465a10b1d5a5f0eab7c9fd5303</citedby><cites>FETCH-LOGICAL-c3955-2429c8ffcad9799bdac4271b7c46bf1663440a6465a10b1d5a5f0eab7c9fd5303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.13495$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.13495$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33237574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borghese, Giulia</creatorcontrib><creatorcontrib>Raffone, Antonio</creatorcontrib><creatorcontrib>Raimondo, Diego</creatorcontrib><creatorcontrib>Saccone, Gabriele</creatorcontrib><creatorcontrib>Travaglino, Antonio</creatorcontrib><creatorcontrib>Degli Esposti, Eugenia</creatorcontrib><creatorcontrib>Mastronardi, Manuela</creatorcontrib><creatorcontrib>Salucci, Paolo</creatorcontrib><creatorcontrib>Zullo, Fulvio</creatorcontrib><creatorcontrib>Seracchioli, Renato</creatorcontrib><title>Adhesion barriers in laparoscopic myomectomy: Evidence from randomized clinical trials</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
To evaluate the effectiveness of different adhesion barriers in the prevention of de novo adhesion development after laparoscopic myomectomy.
Methods
A systematic review was performed by searching seven electronic databases for all randomized clinical trials (RCTs) comparing the use of any absorbable adhesion barrier (i.e. intervention group) with either no treatment or placebo (i.e. control group) in the prevention of adhesion development after laparoscopic myomectomy.
Results
Eight RCTs with a total of 748 participants (392 in the intervention group and 356 in the control group) were included. The assessed adhesion barrier methods were: oxidized regenerated cellulose (ORC) in two studies, auto‐crosslinked hyaluronic acid (HA) gel in two studies, 4% icodextrin solution in one study, modified HA and carboxy‐methylcellulose in one study, polyethylene glycol ester trilysine amine solution plus a borate buffer solution in one study, and polyethylene glycol amine plus dextran aldehyde polymers in another study.
Conclusion
Adhesion barrier methods showing the most promising results were: ORC, auto‐crosslinked HA gel, and polyethylene glycol amine plus dextran aldehyde polymers.
Synopsis
Most promising adhesion barriers after laparoscopic myomectomy are oxidized regenerated cellulose, auto‐crosslinked hyaluronic acid gel, and polyethylene glycol amine plus dextran aldehyde polymers.</description><subject>Cellulose, Oxidized - administration & dosage</subject><subject>Databases, Factual</subject><subject>Device</subject><subject>Female</subject><subject>Fibroid</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Laparoscopy - adverse effects</subject><subject>Myoma</subject><subject>Prevention</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Surgery</subject><subject>Tissue Adhesions - etiology</subject><subject>Tissue Adhesions - prevention & control</subject><subject>Uterine Myomectomy - adverse effects</subject><subject>Uterus</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LwzAYh4Mobk4vfgDJUYTO_GuzeBtjzslgF_Ua0iTVjLapyabUT29np0dP7-H38MD7AHCJ0RgjRG7d5tWPMWUiPQJDPOEioYyLYzDsRpRwIsgAnMW4QQhhjvEpGFBKKE85G4KXqXmz0fka5ioEZ0OEroalalTwUfvGaVi1vrJ666v2Ds4_nLG1trAIvoJB1cZX7ssaqEtXO61KuA1OlfEcnBTdsReHOwLP9_On2UOyWi-Ws-kq0VSkaUIYEXpSFFoZwYXIjdKMcJxzzbK8wFlGGUMqY1mqMMqxSVVaIKu6XRQmpYiOwHXvbYJ_39m4lZWL2palqq3fRUlYxrBgXZwOvelR3X0Wgy1kE1ylQisxkvuOct9R_nTs4KuDd5dX1vyhv-E6APfApytt-49KLh8X6176DSJMfrI</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Borghese, Giulia</creator><creator>Raffone, Antonio</creator><creator>Raimondo, Diego</creator><creator>Saccone, Gabriele</creator><creator>Travaglino, Antonio</creator><creator>Degli Esposti, Eugenia</creator><creator>Mastronardi, Manuela</creator><creator>Salucci, Paolo</creator><creator>Zullo, Fulvio</creator><creator>Seracchioli, Renato</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202103</creationdate><title>Adhesion barriers in laparoscopic myomectomy: Evidence from randomized clinical trials</title><author>Borghese, Giulia ; Raffone, Antonio ; Raimondo, Diego ; Saccone, Gabriele ; Travaglino, Antonio ; Degli Esposti, Eugenia ; Mastronardi, Manuela ; Salucci, Paolo ; Zullo, Fulvio ; Seracchioli, Renato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3955-2429c8ffcad9799bdac4271b7c46bf1663440a6465a10b1d5a5f0eab7c9fd5303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cellulose, Oxidized - administration & dosage</topic><topic>Databases, Factual</topic><topic>Device</topic><topic>Female</topic><topic>Fibroid</topic><topic>Gynecology</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Laparoscopy - adverse effects</topic><topic>Myoma</topic><topic>Prevention</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Surgery</topic><topic>Tissue Adhesions - etiology</topic><topic>Tissue Adhesions - prevention & control</topic><topic>Uterine Myomectomy - adverse effects</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borghese, Giulia</creatorcontrib><creatorcontrib>Raffone, Antonio</creatorcontrib><creatorcontrib>Raimondo, Diego</creatorcontrib><creatorcontrib>Saccone, Gabriele</creatorcontrib><creatorcontrib>Travaglino, Antonio</creatorcontrib><creatorcontrib>Degli Esposti, Eugenia</creatorcontrib><creatorcontrib>Mastronardi, Manuela</creatorcontrib><creatorcontrib>Salucci, Paolo</creatorcontrib><creatorcontrib>Zullo, Fulvio</creatorcontrib><creatorcontrib>Seracchioli, Renato</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borghese, Giulia</au><au>Raffone, Antonio</au><au>Raimondo, Diego</au><au>Saccone, Gabriele</au><au>Travaglino, Antonio</au><au>Degli Esposti, Eugenia</au><au>Mastronardi, Manuela</au><au>Salucci, Paolo</au><au>Zullo, Fulvio</au><au>Seracchioli, Renato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adhesion barriers in laparoscopic myomectomy: Evidence from randomized clinical trials</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2021-03</date><risdate>2021</risdate><volume>152</volume><issue>3</issue><spage>308</spage><epage>320</epage><pages>308-320</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><abstract>Objective
To evaluate the effectiveness of different adhesion barriers in the prevention of de novo adhesion development after laparoscopic myomectomy.
Methods
A systematic review was performed by searching seven electronic databases for all randomized clinical trials (RCTs) comparing the use of any absorbable adhesion barrier (i.e. intervention group) with either no treatment or placebo (i.e. control group) in the prevention of adhesion development after laparoscopic myomectomy.
Results
Eight RCTs with a total of 748 participants (392 in the intervention group and 356 in the control group) were included. The assessed adhesion barrier methods were: oxidized regenerated cellulose (ORC) in two studies, auto‐crosslinked hyaluronic acid (HA) gel in two studies, 4% icodextrin solution in one study, modified HA and carboxy‐methylcellulose in one study, polyethylene glycol ester trilysine amine solution plus a borate buffer solution in one study, and polyethylene glycol amine plus dextran aldehyde polymers in another study.
Conclusion
Adhesion barrier methods showing the most promising results were: ORC, auto‐crosslinked HA gel, and polyethylene glycol amine plus dextran aldehyde polymers.
Synopsis
Most promising adhesion barriers after laparoscopic myomectomy are oxidized regenerated cellulose, auto‐crosslinked hyaluronic acid gel, and polyethylene glycol amine plus dextran aldehyde polymers.</abstract><cop>United States</cop><pmid>33237574</pmid><doi>10.1002/ijgo.13495</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cellulose, Oxidized - administration & dosage Databases, Factual Device Female Fibroid Gynecology Humans Laparoscopy Laparoscopy - adverse effects Myoma Prevention Randomized Controlled Trials as Topic Surgery Tissue Adhesions - etiology Tissue Adhesions - prevention & control Uterine Myomectomy - adverse effects Uterus |
| title | Adhesion barriers in laparoscopic myomectomy: Evidence from randomized clinical trials |
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