Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc - for Glutathione Synthesis in Lung Cancer

Cancer cells need to generate large amounts of glutathione (GSH) to buffer oxidative stress during tumor development. A rate-limiting step for GSH biosynthesis is cystine uptake via a cystine/glutamate antiporter Xc . Xc is a sodium-independent antiporter passively driven by concentration gradients...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-02, Vol.81 (3), p.552-566
Hauptverfasser:	Guo, Wenzheng, Li, Kaimi, Sun, Beibei, Xu, Dongliang, Tong, Lingfeng, Yin, Huijing, Liao, Yueling, Song, Hongyong, Wang, Tong, Jing, Bo, Hu, Min, Liu, Shuli, Kuang, Yanbin, Ling, Jing, Li, Qi, Wu, Yadi, Wang, Qi, Yao, Feng, Zhou, Binhua P, Lin, Shu-Hai, Deng, Jiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiporters - metabolism Cell Death Cell Line, Tumor Cystine - metabolism Excitatory Amino Acid Transporter 3 - metabolism Glutamic Acid - metabolism Glutamine - deficiency Glutathione - biosynthesis Lung Neoplasms - etiology Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Nude Oxidative Stress Receptors, G-Protein-Coupled Stress, Physiological Up-Regulation
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