Pre-operative serum inflammation-based scores in patients with pituitary adenomas
Objective Full blood count (FBC) and serum inflammation-based scores reflect systemic inflammation and predict outcomes in cancer, but little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in PA patients and investigate their usefulness in predicting...
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| Veröffentlicht in: | Pituitary 2021-06, Vol.24 (3), p.334-350 |
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| creator | Marques, Pedro de Vries, Friso Dekkers, Olaf M. van Furth, Wouter R. Korbonits, Márta Biermasz, Nienke R. Pereira, Alberto M. |
| description | Objective
Full blood count (FBC) and serum inflammation-based scores reflect systemic inflammation and predict outcomes in cancer, but little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in PA patients and investigate their usefulness in predicting challenging disease course.
Methods
We studied 424 PA patients first operated at our centre with available pre-operative biochemical data. Patients with infection, malignancies, autoimmune or haematological conditions were excluded. Inflammation-based scores studied: Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Lymphocyte-to-Monocyte Ratio (LMR), Systemic Immune-Inflammation Index (SII), Neutrophil-Platelet Score (NPS), Prognostic Nutrition Index (PNI), and Glasgow Prognostic Score (GPS).
Results
Cushing’s disease patients had more platelets, leucocytes, neutrophils and monocytes, and higher NLR, NPS and SII. Serum inflammation-based scores didn’t differ among non-Cushing PA subtypes. The glucocorticoid excess severity influenced leucocyte, eosinophil, basophil and platelet counts, and GPS in Cushing’s disease. Patients with functioning non-Cushing PAs with suprasellar extension, cavernous sinus invasion and hypopituitarism had GPS ≥ 1, while NPS ≥ 1 was associated with suprasellar extension. More invasive and difficult to treat corticotrophinomas were associated with fewer platelets pre-operatively ( |
| doi_str_mv | 10.1007/s11102-020-01112-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2464146662</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2464146662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-4a9a7580541046081ac93824a99b431e4b17efc9785df3f4bd09b6c40968fa6a3</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYMozvj4Ay6k4MZN9ObZdimDLxhQQcFdSNtb7dCXSav47412VHDhKpdzv3OSHEIOGJwwgPjUM8aAU-BAIYycqg0yZyoWNJYgNsMsEk2FZI8zsuP9CiDYhNwmMyG4AJ2qObm7dUi7Hp0dqleMPLqxiaq2rG3TBKlraWY9FpHPO4c-bKI-yNgOPnqrhueor4axGqx7j2yBbddYv0e2Slt73F-fu-Th4vx-cUWXN5fXi7MlzUWsBiptamOVgJIMpIaE2TwVCQ9ymknBUGYsxjJP40QVpShlVkCa6VxCqpPSait2yfGU27vuZUQ_mKbyOda1bbEbveFSSya11jygR3_QVTe6NrzOcMW1jJNE60Dxicpd573D0vSuasLXDAPzWbiZCjehcPNVuFHBdLiOHrMGix_Ld8MBEBPgw6p9Qvd79z-xHy76iq8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2526478866</pqid></control><display><type>article</type><title>Pre-operative serum inflammation-based scores in patients with pituitary adenomas</title><source>SpringerLink Journals - AutoHoldings</source><creator>Marques, Pedro ; de Vries, Friso ; Dekkers, Olaf M. ; van Furth, Wouter R. ; Korbonits, Márta ; Biermasz, Nienke R. ; Pereira, Alberto M.</creator><creatorcontrib>Marques, Pedro ; de Vries, Friso ; Dekkers, Olaf M. ; van Furth, Wouter R. ; Korbonits, Márta ; Biermasz, Nienke R. ; Pereira, Alberto M.</creatorcontrib><description>Objective
Full blood count (FBC) and serum inflammation-based scores reflect systemic inflammation and predict outcomes in cancer, but little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in PA patients and investigate their usefulness in predicting challenging disease course.
Methods
We studied 424 PA patients first operated at our centre with available pre-operative biochemical data. Patients with infection, malignancies, autoimmune or haematological conditions were excluded. Inflammation-based scores studied: Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Lymphocyte-to-Monocyte Ratio (LMR), Systemic Immune-Inflammation Index (SII), Neutrophil-Platelet Score (NPS), Prognostic Nutrition Index (PNI), and Glasgow Prognostic Score (GPS).
Results
Cushing’s disease patients had more platelets, leucocytes, neutrophils and monocytes, and higher NLR, NPS and SII. Serum inflammation-based scores didn’t differ among non-Cushing PA subtypes. The glucocorticoid excess severity influenced leucocyte, eosinophil, basophil and platelet counts, and GPS in Cushing’s disease. Patients with functioning non-Cushing PAs with suprasellar extension, cavernous sinus invasion and hypopituitarism had GPS ≥ 1, while NPS ≥ 1 was associated with suprasellar extension. More invasive and difficult to treat corticotrophinomas were associated with fewer platelets pre-operatively (< 299.5 × 10
9
/L predicting multimodal treatment). Non-functioning PA patients who suffered apoplexy had more leucocytes, neutrophils and monocytes, higher GPS ≥ 1 and fewer platelets; re-operated cases had fewer lymphocytes, higher NLR and PLR.
Conclusions
Serum inflammation-based scores may predict invasive/refractory PAs: GPS and PNI in non-functioning and functioning non-Cushing PAs; NPS in functioning non-Cushing PAs; NLR and PLR in non-functioning PAs. Platelets < 299.5 × 10
9
/L predict multimodal treatment in Cushing’s disease. Further studies are needed to confirm these observations.</description><identifier>ISSN: 1386-341X</identifier><identifier>EISSN: 1573-7403</identifier><identifier>DOI: 10.1007/s11102-020-01112-5</identifier><identifier>PMID: 33230695</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adrenocorticotropic hormone ; Cushing syndrome ; Cushing's disease ; Endocrinology ; Glucocorticoids ; Human Physiology ; Hypopituitarism ; Inflammation ; Invasiveness ; Leukocytes (eosinophilic) ; Leukocytes (neutrophilic) ; Lymphocytes ; Medicine ; Medicine & Public Health ; Monocytes ; Nervous system diseases ; Neutrophils ; Pituitary ; Platelets ; Tumors</subject><ispartof>Pituitary, 2021-06, Vol.24 (3), p.334-350</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4a9a7580541046081ac93824a99b431e4b17efc9785df3f4bd09b6c40968fa6a3</citedby><cites>FETCH-LOGICAL-c375t-4a9a7580541046081ac93824a99b431e4b17efc9785df3f4bd09b6c40968fa6a3</cites><orcidid>0000-0002-3660-6093 ; 0000-0001-5208-921X ; 0000-0001-5817-3594 ; 0000-0002-1194-9866 ; 0000-0002-1333-7580 ; 0000-0002-4101-9432 ; 0000-0002-4959-5725</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11102-020-01112-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11102-020-01112-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33230695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marques, Pedro</creatorcontrib><creatorcontrib>de Vries, Friso</creatorcontrib><creatorcontrib>Dekkers, Olaf M.</creatorcontrib><creatorcontrib>van Furth, Wouter R.</creatorcontrib><creatorcontrib>Korbonits, Márta</creatorcontrib><creatorcontrib>Biermasz, Nienke R.</creatorcontrib><creatorcontrib>Pereira, Alberto M.</creatorcontrib><title>Pre-operative serum inflammation-based scores in patients with pituitary adenomas</title><title>Pituitary</title><addtitle>Pituitary</addtitle><addtitle>Pituitary</addtitle><description>Objective
Full blood count (FBC) and serum inflammation-based scores reflect systemic inflammation and predict outcomes in cancer, but little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in PA patients and investigate their usefulness in predicting challenging disease course.
Methods
We studied 424 PA patients first operated at our centre with available pre-operative biochemical data. Patients with infection, malignancies, autoimmune or haematological conditions were excluded. Inflammation-based scores studied: Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Lymphocyte-to-Monocyte Ratio (LMR), Systemic Immune-Inflammation Index (SII), Neutrophil-Platelet Score (NPS), Prognostic Nutrition Index (PNI), and Glasgow Prognostic Score (GPS).
Results
Cushing’s disease patients had more platelets, leucocytes, neutrophils and monocytes, and higher NLR, NPS and SII. Serum inflammation-based scores didn’t differ among non-Cushing PA subtypes. The glucocorticoid excess severity influenced leucocyte, eosinophil, basophil and platelet counts, and GPS in Cushing’s disease. Patients with functioning non-Cushing PAs with suprasellar extension, cavernous sinus invasion and hypopituitarism had GPS ≥ 1, while NPS ≥ 1 was associated with suprasellar extension. More invasive and difficult to treat corticotrophinomas were associated with fewer platelets pre-operatively (< 299.5 × 10
9
/L predicting multimodal treatment). Non-functioning PA patients who suffered apoplexy had more leucocytes, neutrophils and monocytes, higher GPS ≥ 1 and fewer platelets; re-operated cases had fewer lymphocytes, higher NLR and PLR.
Conclusions
Serum inflammation-based scores may predict invasive/refractory PAs: GPS and PNI in non-functioning and functioning non-Cushing PAs; NPS in functioning non-Cushing PAs; NLR and PLR in non-functioning PAs. Platelets < 299.5 × 10
9
/L predict multimodal treatment in Cushing’s disease. Further studies are needed to confirm these observations.</description><subject>Adrenocorticotropic hormone</subject><subject>Cushing syndrome</subject><subject>Cushing's disease</subject><subject>Endocrinology</subject><subject>Glucocorticoids</subject><subject>Human Physiology</subject><subject>Hypopituitarism</subject><subject>Inflammation</subject><subject>Invasiveness</subject><subject>Leukocytes (eosinophilic)</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Monocytes</subject><subject>Nervous system diseases</subject><subject>Neutrophils</subject><subject>Pituitary</subject><subject>Platelets</subject><subject>Tumors</subject><issn>1386-341X</issn><issn>1573-7403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kEtLxDAUhYMozvj4Ay6k4MZN9ObZdimDLxhQQcFdSNtb7dCXSav47412VHDhKpdzv3OSHEIOGJwwgPjUM8aAU-BAIYycqg0yZyoWNJYgNsMsEk2FZI8zsuP9CiDYhNwmMyG4AJ2qObm7dUi7Hp0dqleMPLqxiaq2rG3TBKlraWY9FpHPO4c-bKI-yNgOPnqrhueor4axGqx7j2yBbddYv0e2Slt73F-fu-Th4vx-cUWXN5fXi7MlzUWsBiptamOVgJIMpIaE2TwVCQ9ymknBUGYsxjJP40QVpShlVkCa6VxCqpPSait2yfGU27vuZUQ_mKbyOda1bbEbveFSSya11jygR3_QVTe6NrzOcMW1jJNE60Dxicpd573D0vSuasLXDAPzWbiZCjehcPNVuFHBdLiOHrMGix_Ld8MBEBPgw6p9Qvd79z-xHy76iq8</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Marques, Pedro</creator><creator>de Vries, Friso</creator><creator>Dekkers, Olaf M.</creator><creator>van Furth, Wouter R.</creator><creator>Korbonits, Márta</creator><creator>Biermasz, Nienke R.</creator><creator>Pereira, Alberto M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3660-6093</orcidid><orcidid>https://orcid.org/0000-0001-5208-921X</orcidid><orcidid>https://orcid.org/0000-0001-5817-3594</orcidid><orcidid>https://orcid.org/0000-0002-1194-9866</orcidid><orcidid>https://orcid.org/0000-0002-1333-7580</orcidid><orcidid>https://orcid.org/0000-0002-4101-9432</orcidid><orcidid>https://orcid.org/0000-0002-4959-5725</orcidid></search><sort><creationdate>20210601</creationdate><title>Pre-operative serum inflammation-based scores in patients with pituitary adenomas</title><author>Marques, Pedro ; de Vries, Friso ; Dekkers, Olaf M. ; van Furth, Wouter R. ; Korbonits, Márta ; Biermasz, Nienke R. ; Pereira, Alberto M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4a9a7580541046081ac93824a99b431e4b17efc9785df3f4bd09b6c40968fa6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adrenocorticotropic hormone</topic><topic>Cushing syndrome</topic><topic>Cushing's disease</topic><topic>Endocrinology</topic><topic>Glucocorticoids</topic><topic>Human Physiology</topic><topic>Hypopituitarism</topic><topic>Inflammation</topic><topic>Invasiveness</topic><topic>Leukocytes (eosinophilic)</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Monocytes</topic><topic>Nervous system diseases</topic><topic>Neutrophils</topic><topic>Pituitary</topic><topic>Platelets</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marques, Pedro</creatorcontrib><creatorcontrib>de Vries, Friso</creatorcontrib><creatorcontrib>Dekkers, Olaf M.</creatorcontrib><creatorcontrib>van Furth, Wouter R.</creatorcontrib><creatorcontrib>Korbonits, Márta</creatorcontrib><creatorcontrib>Biermasz, Nienke R.</creatorcontrib><creatorcontrib>Pereira, Alberto M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pituitary</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marques, Pedro</au><au>de Vries, Friso</au><au>Dekkers, Olaf M.</au><au>van Furth, Wouter R.</au><au>Korbonits, Márta</au><au>Biermasz, Nienke R.</au><au>Pereira, Alberto M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-operative serum inflammation-based scores in patients with pituitary adenomas</atitle><jtitle>Pituitary</jtitle><stitle>Pituitary</stitle><addtitle>Pituitary</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>24</volume><issue>3</issue><spage>334</spage><epage>350</epage><pages>334-350</pages><issn>1386-341X</issn><eissn>1573-7403</eissn><abstract>Objective
Full blood count (FBC) and serum inflammation-based scores reflect systemic inflammation and predict outcomes in cancer, but little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in PA patients and investigate their usefulness in predicting challenging disease course.
Methods
We studied 424 PA patients first operated at our centre with available pre-operative biochemical data. Patients with infection, malignancies, autoimmune or haematological conditions were excluded. Inflammation-based scores studied: Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Lymphocyte-to-Monocyte Ratio (LMR), Systemic Immune-Inflammation Index (SII), Neutrophil-Platelet Score (NPS), Prognostic Nutrition Index (PNI), and Glasgow Prognostic Score (GPS).
Results
Cushing’s disease patients had more platelets, leucocytes, neutrophils and monocytes, and higher NLR, NPS and SII. Serum inflammation-based scores didn’t differ among non-Cushing PA subtypes. The glucocorticoid excess severity influenced leucocyte, eosinophil, basophil and platelet counts, and GPS in Cushing’s disease. Patients with functioning non-Cushing PAs with suprasellar extension, cavernous sinus invasion and hypopituitarism had GPS ≥ 1, while NPS ≥ 1 was associated with suprasellar extension. More invasive and difficult to treat corticotrophinomas were associated with fewer platelets pre-operatively (< 299.5 × 10
9
/L predicting multimodal treatment). Non-functioning PA patients who suffered apoplexy had more leucocytes, neutrophils and monocytes, higher GPS ≥ 1 and fewer platelets; re-operated cases had fewer lymphocytes, higher NLR and PLR.
Conclusions
Serum inflammation-based scores may predict invasive/refractory PAs: GPS and PNI in non-functioning and functioning non-Cushing PAs; NPS in functioning non-Cushing PAs; NLR and PLR in non-functioning PAs. Platelets < 299.5 × 10
9
/L predict multimodal treatment in Cushing’s disease. Further studies are needed to confirm these observations.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33230695</pmid><doi>10.1007/s11102-020-01112-5</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-3660-6093</orcidid><orcidid>https://orcid.org/0000-0001-5208-921X</orcidid><orcidid>https://orcid.org/0000-0001-5817-3594</orcidid><orcidid>https://orcid.org/0000-0002-1194-9866</orcidid><orcidid>https://orcid.org/0000-0002-1333-7580</orcidid><orcidid>https://orcid.org/0000-0002-4101-9432</orcidid><orcidid>https://orcid.org/0000-0002-4959-5725</orcidid></addata></record> |
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| subjects | Adrenocorticotropic hormone Cushing syndrome Cushing's disease Endocrinology Glucocorticoids Human Physiology Hypopituitarism Inflammation Invasiveness Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lymphocytes Medicine Medicine & Public Health Monocytes Nervous system diseases Neutrophils Pituitary Platelets Tumors |
| title | Pre-operative serum inflammation-based scores in patients with pituitary adenomas |
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