Inhibiting RRM2 to enhance the anticancer activity of chemotherapy

[Display omitted] •RRM2 can be used as a biomarker of chemotherapy response and prognosis.•RRM2 is upregulated by gene, transcriptional and post-transcriptional levels.•Overexpression of RRM2 facilitates DNA damage repair and affects signaling pathway.•SiRNA, RRM2 inhibitors and kinase inhibitors su...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-01, Vol.133, p.110996-110996, Article 110996
Hauptverfasser:	Zhan, Yaqiong, Jiang, Lushun, Jin, Xuehang, Ying, Shuaibing, Wu, Zhe, Wang, Li, Yu, Wei, Tong, Jiepeng, Zhang, Li, Lou, Yan, Qiu, Yunqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Chemoresistance Chemotherapy DNA Damage DNA Repair Drug Resistance, Neoplasm Enzyme Inhibitors - therapeutic use Gene Expression Regulation, Neoplastic Humans Kinase inhibitors Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Protein Kinase Inhibitors - therapeutic use Ribonucleoside Diphosphate Reductase - antagonists & inhibitors Ribonucleoside Diphosphate Reductase - genetics Ribonucleoside Diphosphate Reductase - metabolism Ribonucleotide reductase subunit M2 RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RRM2 inhibitors Signal Transduction Small interfering RNA
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