Liver Macrophages Stimulate the Expression of Hepatocyte Nuclear Factor-6 and Promote Hepatocyte Proliferation at the Early Stage of Liver Regeneration
Hepatocyte nuclear factor (HNF-6) is a liver-specific protein and a key component in the differentiation process during the development of mature liver. The immunohistochemical staining and RT-PCR techniques were employed to examine the expression of HNF-6 and proliferation of Ki-67 + cells during t...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2020-11, Vol.170 (1), p.40-45 |
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| creator | Peng, Y. Ch Lv, T. H. Du, Zh. K. Cun, X. N. Yang, K. M. |
| description | Hepatocyte nuclear factor (HNF-6) is a liver-specific protein and a key component in the differentiation process during the development of mature liver. The immunohistochemical staining and RT-PCR techniques were employed to examine the expression of HNF-6 and proliferation of Ki-67
+
cells during the early regeneration of the liver on postsurgery in 3, 6, 12, and 24 h in original model of partial hepatectomy in rats. The earliest proliferating (Ki-67
+
) cells were observed in 3 h after surgery in liver sinusoids (liver macrophages) and then in liver parenchyma. Expression of HNF-6 in hepatocytes and epithelial cells of the bile ducts attained maximum in 6 h after surgery. At later terms, this parameter somewhat decreased, but still surpassed the control level. |
| doi_str_mv | 10.1007/s10517-020-05000-7 |
| format | Article |
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+
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At later terms, this parameter somewhat decreased, but still surpassed the control level.</description><subject>Bile ducts</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell proliferation</subject><subject>Epithelial cells</subject><subject>Hepatectomy</subject><subject>Hepatocytes</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Liver</subject><subject>Macrophages</subject><subject>Parenchyma</subject><subject>Pathology</subject><subject>Polymerase chain reaction</subject><subject>Surgery</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kttu1DAQhiMEEkvhBbiKhIS4SfExdi6rqqVIy0Ecrq2JM9lN5cSL7VTsk_C6OKRSW4SQLyyPv_8fe2aK4iUlp5QQ9TZSIqmqCCMVkYSQSj0qNlQqXmnG6ONik2OqElrrp8WzGK-XI6nppvi1HW4wlB_ABn_Yww5j-TUN4-wgYZn2WF78PASMcfBT6fvyCg-QvD3my4-zdQihvASbfKjqEqau_Bz86PPlPS6H3NBjgLR4QFpdIbhjzpQTLrbrI77gDqdb8HnxpAcX8cXtflJ8v7z4dn5VbT-9e39-tq2skCRVgrfAtBW6gVZAJ7Ftu1yKtrGMMw2kg5pzrXTDO-QMLNVNLZBaKRpNhOr4SfFm9T0E_2PGmMw4RIvOwYR-joaJmtekllxk9NVf6LWfw5RflynFuVQNY3fUDhyaYep9CmAXU3NWSypp7ofM1Ok_qLw6HAfrJ-yHHH8geH1PsEdwaR-9m5daxYcgW8Hc0BgD9uYQhhHC0VBillkx66yYPCvmz6wYlUV8FcUMTzsMd1_7j-o3yubAJg</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Peng, Y. 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+
cells during the early regeneration of the liver on postsurgery in 3, 6, 12, and 24 h in original model of partial hepatectomy in rats. The earliest proliferating (Ki-67
+
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| subjects | Bile ducts Biomedical and Life Sciences Biomedicine Cell Biology Cell proliferation Epithelial cells Hepatectomy Hepatocytes Immunohistochemistry Internal Medicine Laboratory Medicine Liver Macrophages Parenchyma Pathology Polymerase chain reaction Surgery |
| title | Liver Macrophages Stimulate the Expression of Hepatocyte Nuclear Factor-6 and Promote Hepatocyte Proliferation at the Early Stage of Liver Regeneration |
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