Do serum GDNF levels correlate with severity of Alzheimer’s disease?

Introduction A growing body of evidence that glial cell line–derived neurotrophic factor (GDNF) levels are probably involved in pathogenesis and disease course of Alzheimer’s disease (AD) suggested that its blood levels could potentially be used as a biomarker of AD. The aim of this study was to compare serum GDNF levels in patients with AD and age-matched controls. Methods Serum concentrations of GDNF were compared in 25 AD patients and 25 healthy volunteers using a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Severity of the disease in AD patients was assessed using Functional Assessment Staging (FAST). Cognitive assessment of the patients was done using the Mini-Mental State Examination (MMSE). Results Mean GDNF levels were found to be 2.45 ± 0.93 ng/ml in AD patients and 4.61 ± 3.39 ng/ml in age-matched controls. There was a statistically significant difference in GDNF serum levels in patients with AD compared to age-matched controls ( p = 0.001). Moreover, GDNF serum levels were significantly correlated with disease severity ( p