Development of Indoleamine 2,3-Dioxygenase 1 Inhibitors for Cancer Therapy and Beyond: A Recent Perspective

Indoleamine 2,3-dioxygenase 1 (IDO1) has received increasing attention due to its immunosuppressive function in connection with various diseases, including cancer. A recent increase in the understanding of IDO1 has significantly contributed to the discovery of numerous novel inhibitors, but the late...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2020-12, Vol.63 (24), p.15115-15139
Hauptverfasser:	Feng, Xi, Liao, Dongdong, Liu, Dongyu, Ping, An, Li, Zhiyu, Bian, Jinlei
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Catalytic Domain Drug Discovery Enzyme Inhibitors - chemistry Enzyme Inhibitors - therapeutic use Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Indoles - chemistry Indoles - therapeutic use Molecular Docking Simulation Neoplasms - drug therapy Neoplasms - pathology Small Molecule Libraries - chemistry Small Molecule Libraries - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!