In vitro and in vivo anti-inflammatory effect of Zaluzanin D isolated from Achillea acuminate

•Z.D pretreatment leaded a significant reduction of inflammatory response.•Z.D inhibited lipid peroxidation and recruited the anti-oxidative defense system.•Z.D down-regulated cytokines by inhibiting the nuclear translocation of of NF-κB. The present study was investigated to verify anti-inflammator...

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Veröffentlicht in:	International immunopharmacology 2021-01, Vol.90, p.107130-107130, Article 107130
Hauptverfasser:	Wang, Yongjie, Zhang, Jiaozhen, Gao, Xinli, Li, Qiang, Sun, Deqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Achillea - chemistry Active Transport, Cell Nucleus Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antioxidants - isolation & purification Antioxidants - pharmacology Cell Line Cytokines Cytokines - metabolism Disease Models, Animal IL-1β Immunoregulation Inflammation Inflammation Mediators - metabolism Interleukin 6 Intravenous administration Lipid peroxidation Lipid Peroxidation - drug effects Lipids Lipopolysaccharides Lungs Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Male NF-kappa B - metabolism NF-κB protein Nitric oxide Nuclear factor-kappa B Oxidative state Peroxidation Pneumonia - immunology Pneumonia - metabolism Pneumonia - prevention & control Pulmonary inflammatory Rats Rats, Sprague-Dawley Secretions Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Tumor necrosis factor-α Zaluzanin D
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