In vitro and in vivo anti-inflammatory effect of Zaluzanin D isolated from Achillea acuminate
•Z.D pretreatment leaded a significant reduction of inflammatory response.•Z.D inhibited lipid peroxidation and recruited the anti-oxidative defense system.•Z.D down-regulated cytokines by inhibiting the nuclear translocation of of NF-κB. The present study was investigated to verify anti-inflammator...
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| Veröffentlicht in: | International immunopharmacology 2021-01, Vol.90, p.107130-107130, Article 107130 |
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| creator | Wang, Yongjie Zhang, Jiaozhen Gao, Xinli Li, Qiang Sun, Deqing |
| description | •Z.D pretreatment leaded a significant reduction of inflammatory response.•Z.D inhibited lipid peroxidation and recruited the anti-oxidative defense system.•Z.D down-regulated cytokines by inhibiting the nuclear translocation of of NF-κB.
The present study was investigated to verify anti-inflammatory and immune regulation effect of Zaluzanin D on LPS-induced macrophages and acute lung injury. NR8383 macrophages were pre-treated with Zaluzanin D and stimulated by LPS. Zaluzanin D reduced the production of nitric oxide in NR8383 macrophages and decreased the secretions of inflammatory cytokines. In addition, intravenous of Zaluzanin D to LPS-induced rats reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, Z.D inhibited lipid peroxidation and effectively recruit the anti-oxidative defense system, regulated the levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the lungs by inhibitory expression of nuclear factor-kappa B pathway. These findings suggested that Zaluzanin D attenuated pulmonary inflammatory responses by inhibiting the expression of diverse inflammatory mediators in vitro and in vivo. |
| doi_str_mv | 10.1016/j.intimp.2020.107130 |
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The present study was investigated to verify anti-inflammatory and immune regulation effect of Zaluzanin D on LPS-induced macrophages and acute lung injury. NR8383 macrophages were pre-treated with Zaluzanin D and stimulated by LPS. Zaluzanin D reduced the production of nitric oxide in NR8383 macrophages and decreased the secretions of inflammatory cytokines. In addition, intravenous of Zaluzanin D to LPS-induced rats reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, Z.D inhibited lipid peroxidation and effectively recruit the anti-oxidative defense system, regulated the levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the lungs by inhibitory expression of nuclear factor-kappa B pathway. These findings suggested that Zaluzanin D attenuated pulmonary inflammatory responses by inhibiting the expression of diverse inflammatory mediators in vitro and in vivo.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2020.107130</identifier><identifier>PMID: 33218937</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Achillea - chemistry ; Active Transport, Cell Nucleus ; Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Cell Line ; Cytokines ; Cytokines - metabolism ; Disease Models, Animal ; IL-1β ; Immunoregulation ; Inflammation ; Inflammation Mediators - metabolism ; Interleukin 6 ; Intravenous administration ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids ; Lipopolysaccharides ; Lungs ; Macrophages ; Macrophages - drug effects ; Macrophages - immunology ; Macrophages - metabolism ; Male ; NF-kappa B - metabolism ; NF-κB protein ; Nitric oxide ; Nuclear factor-kappa B ; Oxidative state ; Peroxidation ; Pneumonia - immunology ; Pneumonia - metabolism ; Pneumonia - prevention & control ; Pulmonary inflammatory ; Rats ; Rats, Sprague-Dawley ; Secretions ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology ; Tumor necrosis factor-α ; Zaluzanin D</subject><ispartof>International immunopharmacology, 2021-01, Vol.90, p.107130-107130, Article 107130</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jan 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-c323eb9bc40bb73dede03803574bc5e8b065e1ce275877af83b8ffb5ff8304e93</citedby><cites>FETCH-LOGICAL-c390t-c323eb9bc40bb73dede03803574bc5e8b065e1ce275877af83b8ffb5ff8304e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2020.107130$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33218937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yongjie</creatorcontrib><creatorcontrib>Zhang, Jiaozhen</creatorcontrib><creatorcontrib>Gao, Xinli</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Sun, Deqing</creatorcontrib><title>In vitro and in vivo anti-inflammatory effect of Zaluzanin D isolated from Achillea acuminate</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>•Z.D pretreatment leaded a significant reduction of inflammatory response.•Z.D inhibited lipid peroxidation and recruited the anti-oxidative defense system.•Z.D down-regulated cytokines by inhibiting the nuclear translocation of of NF-κB.
The present study was investigated to verify anti-inflammatory and immune regulation effect of Zaluzanin D on LPS-induced macrophages and acute lung injury. NR8383 macrophages were pre-treated with Zaluzanin D and stimulated by LPS. Zaluzanin D reduced the production of nitric oxide in NR8383 macrophages and decreased the secretions of inflammatory cytokines. In addition, intravenous of Zaluzanin D to LPS-induced rats reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, Z.D inhibited lipid peroxidation and effectively recruit the anti-oxidative defense system, regulated the levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the lungs by inhibitory expression of nuclear factor-kappa B pathway. These findings suggested that Zaluzanin D attenuated pulmonary inflammatory responses by inhibiting the expression of diverse inflammatory mediators in vitro and in vivo.</description><subject>Achillea - chemistry</subject><subject>Active Transport, Cell Nucleus</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Cell Line</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>IL-1β</subject><subject>Immunoregulation</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin 6</subject><subject>Intravenous administration</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Lipopolysaccharides</subject><subject>Lungs</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Nitric oxide</subject><subject>Nuclear factor-kappa B</subject><subject>Oxidative state</subject><subject>Peroxidation</subject><subject>Pneumonia - immunology</subject><subject>Pneumonia - metabolism</subject><subject>Pneumonia - prevention & control</subject><subject>Pulmonary inflammatory</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Secretions</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Tumor necrosis factor-α</subject><subject>Zaluzanin D</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqFTEUhoMotra-gUjAjZu5nkwmk5mNUFqthYKbuhFKSDInmMtMck1mLtSnb4apLrpwk_w5-c5J-Ah5x2DHgLWf9jsfZj8ddjXUa0kyDi_IKetkVzEJ4mXJopWVkG1_Qt7kvAco9Ya9Jiec16zruTwl9zeBHv2cItVhoH49HNc8-8oHN-pp0nNMDxSdQzvT6OhPPS5_dCjoFfU5jnrGgboUJ3phf_lxRE21XSYfysU5eeX0mPHt035Gfnz9cnf5rbr9fn1zeXFbWd7DXNaao-mNbcAYyQccEHgHXMjGWIGdgVYgs1hL0UmpXcdN55wRriRosOdn5OM295Di7wXzrCafLY6jDhiXrOqm5QwEhxX98AzdxyWF8rtC9awtFlsoVLNRNsWcEzp1SH7S6UExUKt-tVebfrXqV5v-0vb-afhiJhz-Nf31XYDPG4DFxtFjUtl6DBYHn4pfNUT__xceAfobl7o</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Wang, Yongjie</creator><creator>Zhang, Jiaozhen</creator><creator>Gao, Xinli</creator><creator>Li, Qiang</creator><creator>Sun, Deqing</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202101</creationdate><title>In vitro and in vivo anti-inflammatory effect of Zaluzanin D isolated from Achillea acuminate</title><author>Wang, Yongjie ; Zhang, Jiaozhen ; Gao, Xinli ; Li, Qiang ; Sun, Deqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-c323eb9bc40bb73dede03803574bc5e8b065e1ce275877af83b8ffb5ff8304e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Achillea - chemistry</topic><topic>Active Transport, Cell Nucleus</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Cell Line</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>IL-1β</topic><topic>Immunoregulation</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukin 6</topic><topic>Intravenous administration</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids</topic><topic>Lipopolysaccharides</topic><topic>Lungs</topic><topic>Macrophages</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Nitric oxide</topic><topic>Nuclear factor-kappa B</topic><topic>Oxidative state</topic><topic>Peroxidation</topic><topic>Pneumonia - immunology</topic><topic>Pneumonia - metabolism</topic><topic>Pneumonia - prevention & control</topic><topic>Pulmonary inflammatory</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Secretions</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Tumor necrosis factor-α</topic><topic>Zaluzanin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yongjie</creatorcontrib><creatorcontrib>Zhang, Jiaozhen</creatorcontrib><creatorcontrib>Gao, Xinli</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Sun, Deqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yongjie</au><au>Zhang, Jiaozhen</au><au>Gao, Xinli</au><au>Li, Qiang</au><au>Sun, Deqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo anti-inflammatory effect of Zaluzanin D isolated from Achillea acuminate</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>90</volume><spage>107130</spage><epage>107130</epage><pages>107130-107130</pages><artnum>107130</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>•Z.D pretreatment leaded a significant reduction of inflammatory response.•Z.D inhibited lipid peroxidation and recruited the anti-oxidative defense system.•Z.D down-regulated cytokines by inhibiting the nuclear translocation of of NF-κB.
The present study was investigated to verify anti-inflammatory and immune regulation effect of Zaluzanin D on LPS-induced macrophages and acute lung injury. NR8383 macrophages were pre-treated with Zaluzanin D and stimulated by LPS. Zaluzanin D reduced the production of nitric oxide in NR8383 macrophages and decreased the secretions of inflammatory cytokines. In addition, intravenous of Zaluzanin D to LPS-induced rats reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, Z.D inhibited lipid peroxidation and effectively recruit the anti-oxidative defense system, regulated the levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the lungs by inhibitory expression of nuclear factor-kappa B pathway. These findings suggested that Zaluzanin D attenuated pulmonary inflammatory responses by inhibiting the expression of diverse inflammatory mediators in vitro and in vivo.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33218937</pmid><doi>10.1016/j.intimp.2020.107130</doi><tpages>1</tpages></addata></record> |
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| subjects | Achillea - chemistry Active Transport, Cell Nucleus Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antioxidants - isolation & purification Antioxidants - pharmacology Cell Line Cytokines Cytokines - metabolism Disease Models, Animal IL-1β Immunoregulation Inflammation Inflammation Mediators - metabolism Interleukin 6 Intravenous administration Lipid peroxidation Lipid Peroxidation - drug effects Lipids Lipopolysaccharides Lungs Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Male NF-kappa B - metabolism NF-κB protein Nitric oxide Nuclear factor-kappa B Oxidative state Peroxidation Pneumonia - immunology Pneumonia - metabolism Pneumonia - prevention & control Pulmonary inflammatory Rats Rats, Sprague-Dawley Secretions Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Tumor necrosis factor-α Zaluzanin D |
| title | In vitro and in vivo anti-inflammatory effect of Zaluzanin D isolated from Achillea acuminate |
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