Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin
The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms. The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry tec...
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| Veröffentlicht in: | Future microbiology 2020-11, Vol.15 (17), p.1611-1619 |
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| creator | Av Sá, Lívia G do Silva, Cecília R da de A Neto, João B Cândido, Thiago M de Oliveira, Leilson C do Nascimento, Francisca Bsa Barroso, Fátima Dd da Silva, Lisandra J de Mesquita, Jacó Rl de Moraes, Manoel O Cavalcanti, Bruno C Júnior, Hélio Vn |
| description | The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms.
The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used.
MRSA strains showed MIC equal to 500 and 1000 μg/ml of etomidate. Four-fifths (80%) of the tested MRSA strains demonstrated synergistic effect with oxacillin. Etomidate also showed activity against MRSA biofilm at concentration of 250 μg/ml. Cytometric analysis revealed that the cells treated with etomidate leading to cell death, probably by apoptosis.
Etomidate showed antibacterial activity against MRSA. |
| doi_str_mv | 10.2217/fmb-2020-0078 |
| format | Article |
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The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used.
MRSA strains showed MIC equal to 500 and 1000 μg/ml of etomidate. Four-fifths (80%) of the tested MRSA strains demonstrated synergistic effect with oxacillin. Etomidate also showed activity against MRSA biofilm at concentration of 250 μg/ml. Cytometric analysis revealed that the cells treated with etomidate leading to cell death, probably by apoptosis.
Etomidate showed antibacterial activity against MRSA.</description><identifier>ISSN: 1746-0913</identifier><identifier>EISSN: 1746-0921</identifier><identifier>DOI: 10.2217/fmb-2020-0078</identifier><identifier>PMID: 33215536</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Antibacterial activity ; Antibiotics ; Antimicrobial activity ; Antimicrobial agents ; Apoptosis ; apoptosis and antimicrobial ; Biofilms ; Cell death ; Deoxyribonucleic acid ; DNA ; Drug resistance ; Etomidate ; Flow cytometry ; Infections ; methicillin-resistant ; Microorganisms ; Minimum inhibitory concentration ; Oxacillin ; Penicillin ; Salt ; Scanning electron microscopy ; Sodium</subject><ispartof>Future microbiology, 2020-11, Vol.15 (17), p.1611-1619</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Nov 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-7ecbcb10aa3f94fbb20c099eeddaa730c20ace98800f64dc4b412c9c0cf5ac5b3</citedby><cites>FETCH-LOGICAL-c371t-7ecbcb10aa3f94fbb20c099eeddaa730c20ace98800f64dc4b412c9c0cf5ac5b3</cites><orcidid>0000-0002-0619-2782</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33215536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Av Sá, Lívia G do</creatorcontrib><creatorcontrib>Silva, Cecília R da</creatorcontrib><creatorcontrib>de A Neto, João B</creatorcontrib><creatorcontrib>Cândido, Thiago M</creatorcontrib><creatorcontrib>de Oliveira, Leilson C</creatorcontrib><creatorcontrib>do Nascimento, Francisca Bsa</creatorcontrib><creatorcontrib>Barroso, Fátima Dd</creatorcontrib><creatorcontrib>da Silva, Lisandra J</creatorcontrib><creatorcontrib>de Mesquita, Jacó Rl</creatorcontrib><creatorcontrib>de Moraes, Manoel O</creatorcontrib><creatorcontrib>Cavalcanti, Bruno C</creatorcontrib><creatorcontrib>Júnior, Hélio Vn</creatorcontrib><title>Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin</title><title>Future microbiology</title><addtitle>Future Microbiol</addtitle><description>The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms.
The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used.
MRSA strains showed MIC equal to 500 and 1000 μg/ml of etomidate. Four-fifths (80%) of the tested MRSA strains demonstrated synergistic effect with oxacillin. Etomidate also showed activity against MRSA biofilm at concentration of 250 μg/ml. Cytometric analysis revealed that the cells treated with etomidate leading to cell death, probably by apoptosis.
Etomidate showed antibacterial activity against MRSA.</description><subject>Antibacterial activity</subject><subject>Antibiotics</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Apoptosis</subject><subject>apoptosis and antimicrobial</subject><subject>Biofilms</subject><subject>Cell death</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug resistance</subject><subject>Etomidate</subject><subject>Flow cytometry</subject><subject>Infections</subject><subject>methicillin-resistant</subject><subject>Microorganisms</subject><subject>Minimum inhibitory concentration</subject><subject>Oxacillin</subject><subject>Penicillin</subject><subject>Salt</subject><subject>Scanning electron 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Bsa</creator><creator>Barroso, Fátima Dd</creator><creator>da Silva, Lisandra J</creator><creator>de Mesquita, Jacó Rl</creator><creator>de Moraes, Manoel O</creator><creator>Cavalcanti, Bruno C</creator><creator>Júnior, Hélio Vn</creator><general>Future Medicine 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; Silva, Cecília R da ; de A Neto, João B ; Cândido, Thiago M ; de Oliveira, Leilson C ; do Nascimento, Francisca Bsa ; Barroso, Fátima Dd ; da Silva, Lisandra J ; de Mesquita, Jacó Rl ; de Moraes, Manoel O ; Cavalcanti, Bruno C ; Júnior, Hélio Vn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-7ecbcb10aa3f94fbb20c099eeddaa730c20ace98800f64dc4b412c9c0cf5ac5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibacterial activity</topic><topic>Antibiotics</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Apoptosis</topic><topic>apoptosis and antimicrobial</topic><topic>Biofilms</topic><topic>Cell death</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug resistance</topic><topic>Etomidate</topic><topic>Flow 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Microbiol</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>15</volume><issue>17</issue><spage>1611</spage><epage>1619</epage><pages>1611-1619</pages><issn>1746-0913</issn><eissn>1746-0921</eissn><abstract>The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms.
The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used.
MRSA strains showed MIC equal to 500 and 1000 μg/ml of etomidate. Four-fifths (80%) of the tested MRSA strains demonstrated synergistic effect with oxacillin. Etomidate also showed activity against MRSA biofilm at concentration of 250 μg/ml. Cytometric analysis revealed that the cells treated with etomidate leading to cell death, probably by apoptosis.
Etomidate showed antibacterial activity against MRSA.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>33215536</pmid><doi>10.2217/fmb-2020-0078</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0619-2782</orcidid></addata></record> |
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| ispartof | Future microbiology, 2020-11, Vol.15 (17), p.1611-1619 |
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| subjects | Antibacterial activity Antibiotics Antimicrobial activity Antimicrobial agents Apoptosis apoptosis and antimicrobial Biofilms Cell death Deoxyribonucleic acid DNA Drug resistance Etomidate Flow cytometry Infections methicillin-resistant Microorganisms Minimum inhibitory concentration Oxacillin Penicillin Salt Scanning electron microscopy Sodium |
| title | Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin |
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