(-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp
To evaluate the activity of (-)-camphene-based thiosemicarbazide (TSC) and 4-hydroxy-thiosemicarbazone (4-OH-TSZ), alone and in combination against Gram-positive. MIC were determined for , spp. reference strains and clinical isolates. Drug combination, time-kill and cytotoxicity assays were also per...
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| Veröffentlicht in: | Future microbiology 2020-11, Vol.15 (16), p.1527-1534 |
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| creator | de Freitas, Beatriz C Queiroz, Paula A Baldin, Vanessa P do Amaral, Pedro Hr Rodrigues, Lucas Lf Vandresen, Fabio R Caleffi-Ferracioli, Katiany de L Scodro, Regiane B Cardoso, Rosilene F Siqueira, Vera Ld |
| description | To evaluate the activity of (-)-camphene-based thiosemicarbazide (TSC) and 4-hydroxy-thiosemicarbazone (4-OH-TSZ), alone and in combination against Gram-positive.
MIC were determined for
,
spp. reference strains and clinical isolates. Drug combination, time-kill and cytotoxicity assays were also performed.
TSC and 4-OH-TSZ demonstrated potent inhibitory activity against
and
spp., including multidrug-resistant isolates (MIC ranging from 1.9 to 31.2 μg/ml), and were bactericidal for the reference strains of both Gram-positive tested. The derivatives proved to be selective for the bacteria and synergistic with oxacillin and vancomycin.
(-)-Camphene-based derivatives can represent promising drug candidates against critical pathogens, such as
and
spp., including MRSA and vancomycin resistance
spp. isolates. |
| doi_str_mv | 10.2217/fmb-2020-0131 |
| format | Article |
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MIC were determined for
,
spp. reference strains and clinical isolates. Drug combination, time-kill and cytotoxicity assays were also performed.
TSC and 4-OH-TSZ demonstrated potent inhibitory activity against
and
spp., including multidrug-resistant isolates (MIC ranging from 1.9 to 31.2 μg/ml), and were bactericidal for the reference strains of both Gram-positive tested. The derivatives proved to be selective for the bacteria and synergistic with oxacillin and vancomycin.
(-)-Camphene-based derivatives can represent promising drug candidates against critical pathogens, such as
and
spp., including MRSA and vancomycin resistance
spp. isolates.</description><identifier>ISSN: 1746-0913</identifier><identifier>EISSN: 1746-0921</identifier><identifier>DOI: 10.2217/fmb-2020-0131</identifier><identifier>PMID: 33215538</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Antibacterial agents ; Antimicrobial agents ; Bacteria ; Camphene ; Clinical isolates ; Cytotoxicity ; Drug development ; Enterococcus ; Ethanol ; Gram-positive bacteria ; Laboratories ; Minimum inhibitory concentration ; Multidrug resistance ; Oxacillin ; Pathogens ; Staphylococcus aureus ; Staphylococcus infections ; Strains (organisms) ; Vancomycin</subject><ispartof>Future microbiology, 2020-11, Vol.15 (16), p.1527-1534</ispartof><rights>Copyright Future Medicine Ltd Nov 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-7e06e0de29d93d255247f7bb680d7a531cae78debc87fbb7bae8ee896611f80a3</citedby><cites>FETCH-LOGICAL-c321t-7e06e0de29d93d255247f7bb680d7a531cae78debc87fbb7bae8ee896611f80a3</cites><orcidid>0000-0002-0137-2880 ; 0000-0002-9129-2445 ; 0000-0002-6851-1734 ; 0000-0002-4200-6254 ; 0000-0003-0345-1600 ; 0000-0002-8777-5014 ; 0000-0002-0730-7609 ; 0000-0001-7973-4098 ; 0000-0002-8596-7872 ; 0000-0001-6228-4780</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33215538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Freitas, Beatriz C</creatorcontrib><creatorcontrib>Queiroz, Paula A</creatorcontrib><creatorcontrib>Baldin, Vanessa P</creatorcontrib><creatorcontrib>do Amaral, Pedro Hr</creatorcontrib><creatorcontrib>Rodrigues, Lucas Lf</creatorcontrib><creatorcontrib>Vandresen, Fabio</creatorcontrib><creatorcontrib>R Caleffi-Ferracioli, Katiany</creatorcontrib><creatorcontrib>de L Scodro, Regiane B</creatorcontrib><creatorcontrib>Cardoso, Rosilene F</creatorcontrib><creatorcontrib>Siqueira, Vera Ld</creatorcontrib><title>(-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp</title><title>Future microbiology</title><addtitle>Future Microbiol</addtitle><description>To evaluate the activity of (-)-camphene-based thiosemicarbazide (TSC) and 4-hydroxy-thiosemicarbazone (4-OH-TSZ), alone and in combination against Gram-positive.
MIC were determined for
,
spp. reference strains and clinical isolates. Drug combination, time-kill and cytotoxicity assays were also performed.
TSC and 4-OH-TSZ demonstrated potent inhibitory activity against
and
spp., including multidrug-resistant isolates (MIC ranging from 1.9 to 31.2 μg/ml), and were bactericidal for the reference strains of both Gram-positive tested. The derivatives proved to be selective for the bacteria and synergistic with oxacillin and vancomycin.
(-)-Camphene-based derivatives can represent promising drug candidates against critical pathogens, such as
and
spp., including MRSA and vancomycin resistance
spp. isolates.</description><subject>Antibacterial agents</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Camphene</subject><subject>Clinical isolates</subject><subject>Cytotoxicity</subject><subject>Drug development</subject><subject>Enterococcus</subject><subject>Ethanol</subject><subject>Gram-positive bacteria</subject><subject>Laboratories</subject><subject>Minimum inhibitory concentration</subject><subject>Multidrug resistance</subject><subject>Oxacillin</subject><subject>Pathogens</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Strains (organisms)</subject><subject>Vancomycin</subject><issn>1746-0913</issn><issn>1746-0921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUlPwzAQhS0EoqVw5IoicSkHg5ckdo6oKotUiQNwtrxM2lTZiJNK_fc4asuB0xu_-TwazUPolpJHxqh4yiuDGWEEE8rpGZpSEaeYZIye_9WUT9CV91tCEkkzeokmnDOaJFxOkZ_jB7zQVbuBGrDRHlzkoCt2ui924CPto7bpoe4LXUY6iNG2D_3xtQ52INa6qH0fffa63ezLxjbWDsEeOhildtGyDj9Ovm_ba3SR69LDzVFn6Ptl-bV4w6uP1_fF8wrbsF6PBZAUiAOWuYw7liQsFrkwJpXECZ1wajUI6cBYKXJjhNEgAWSWppTmkmg-Q_PD3LZrfgbwvaoKb6EsdQ3N4BWLU04JZUIG9P4fum2Grg7bKZYQHhMu4yRQ-EDZrvG-g1y1XVHpbq8oUWMaKqShxjTUmEbg745TB1OB-6NP5-e_ISuG0g</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>de Freitas, Beatriz C</creator><creator>Queiroz, Paula A</creator><creator>Baldin, Vanessa P</creator><creator>do Amaral, Pedro Hr</creator><creator>Rodrigues, Lucas Lf</creator><creator>Vandresen, Fabio</creator><creator>R Caleffi-Ferracioli, Katiany</creator><creator>de L Scodro, Regiane B</creator><creator>Cardoso, Rosilene F</creator><creator>Siqueira, Vera Ld</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0137-2880</orcidid><orcidid>https://orcid.org/0000-0002-9129-2445</orcidid><orcidid>https://orcid.org/0000-0002-6851-1734</orcidid><orcidid>https://orcid.org/0000-0002-4200-6254</orcidid><orcidid>https://orcid.org/0000-0003-0345-1600</orcidid><orcidid>https://orcid.org/0000-0002-8777-5014</orcidid><orcidid>https://orcid.org/0000-0002-0730-7609</orcidid><orcidid>https://orcid.org/0000-0001-7973-4098</orcidid><orcidid>https://orcid.org/0000-0002-8596-7872</orcidid><orcidid>https://orcid.org/0000-0001-6228-4780</orcidid></search><sort><creationdate>20201101</creationdate><title>(-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp</title><author>de Freitas, Beatriz C ; Queiroz, Paula A ; Baldin, Vanessa P ; do Amaral, Pedro Hr ; Rodrigues, Lucas Lf ; Vandresen, Fabio ; R Caleffi-Ferracioli, Katiany ; de L Scodro, Regiane B ; Cardoso, Rosilene F ; Siqueira, Vera Ld</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-7e06e0de29d93d255247f7bb680d7a531cae78debc87fbb7bae8ee896611f80a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibacterial agents</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Camphene</topic><topic>Clinical isolates</topic><topic>Cytotoxicity</topic><topic>Drug development</topic><topic>Enterococcus</topic><topic>Ethanol</topic><topic>Gram-positive bacteria</topic><topic>Laboratories</topic><topic>Minimum inhibitory concentration</topic><topic>Multidrug resistance</topic><topic>Oxacillin</topic><topic>Pathogens</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><topic>Strains (organisms)</topic><topic>Vancomycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Freitas, Beatriz C</creatorcontrib><creatorcontrib>Queiroz, Paula A</creatorcontrib><creatorcontrib>Baldin, Vanessa P</creatorcontrib><creatorcontrib>do Amaral, Pedro Hr</creatorcontrib><creatorcontrib>Rodrigues, Lucas Lf</creatorcontrib><creatorcontrib>Vandresen, Fabio</creatorcontrib><creatorcontrib>R Caleffi-Ferracioli, Katiany</creatorcontrib><creatorcontrib>de L Scodro, Regiane B</creatorcontrib><creatorcontrib>Cardoso, Rosilene F</creatorcontrib><creatorcontrib>Siqueira, Vera Ld</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Future microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Freitas, Beatriz C</au><au>Queiroz, Paula A</au><au>Baldin, Vanessa P</au><au>do Amaral, Pedro Hr</au><au>Rodrigues, Lucas Lf</au><au>Vandresen, Fabio</au><au>R Caleffi-Ferracioli, Katiany</au><au>de L Scodro, Regiane B</au><au>Cardoso, Rosilene F</au><au>Siqueira, Vera Ld</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp</atitle><jtitle>Future microbiology</jtitle><addtitle>Future Microbiol</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>15</volume><issue>16</issue><spage>1527</spage><epage>1534</epage><pages>1527-1534</pages><issn>1746-0913</issn><eissn>1746-0921</eissn><abstract>To evaluate the activity of (-)-camphene-based thiosemicarbazide (TSC) and 4-hydroxy-thiosemicarbazone (4-OH-TSZ), alone and in combination against Gram-positive.
MIC were determined for
,
spp. reference strains and clinical isolates. Drug combination, time-kill and cytotoxicity assays were also performed.
TSC and 4-OH-TSZ demonstrated potent inhibitory activity against
and
spp., including multidrug-resistant isolates (MIC ranging from 1.9 to 31.2 μg/ml), and were bactericidal for the reference strains of both Gram-positive tested. The derivatives proved to be selective for the bacteria and synergistic with oxacillin and vancomycin.
(-)-Camphene-based derivatives can represent promising drug candidates against critical pathogens, such as
and
spp., including MRSA and vancomycin resistance
spp. isolates.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>33215538</pmid><doi>10.2217/fmb-2020-0131</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0137-2880</orcidid><orcidid>https://orcid.org/0000-0002-9129-2445</orcidid><orcidid>https://orcid.org/0000-0002-6851-1734</orcidid><orcidid>https://orcid.org/0000-0002-4200-6254</orcidid><orcidid>https://orcid.org/0000-0003-0345-1600</orcidid><orcidid>https://orcid.org/0000-0002-8777-5014</orcidid><orcidid>https://orcid.org/0000-0002-0730-7609</orcidid><orcidid>https://orcid.org/0000-0001-7973-4098</orcidid><orcidid>https://orcid.org/0000-0002-8596-7872</orcidid><orcidid>https://orcid.org/0000-0001-6228-4780</orcidid></addata></record> |
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| subjects | Antibacterial agents Antimicrobial agents Bacteria Camphene Clinical isolates Cytotoxicity Drug development Enterococcus Ethanol Gram-positive bacteria Laboratories Minimum inhibitory concentration Multidrug resistance Oxacillin Pathogens Staphylococcus aureus Staphylococcus infections Strains (organisms) Vancomycin |
| title | (-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp |
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