Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents

[Display omitted] •Isatin-thiazolidinone derivatives were designed and synthesized to target cell cycle checkpoint pathways.•E-and Z-diasteromeres of the synthesized molecules were identified and there structures were confirmed.•In vitro cytotoxicity of the prepared compounds was tested against thre...

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Veröffentlicht in:Bioorganic chemistry 2020-12, Vol.105, p.104366-104366, Article 104366
Hauptverfasser: Yousef, Mohamed A., Ali, Ahmed M., El-Sayed, Wael M., Qayed, Wesam S., Farag, Hassan H.A., Aboul-Fadl, Tarek
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Sprache:eng
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