Large‐Scale Synthesis of a Niche Olefin Metathesis Catalyst Bearing an Unsymmetrical N‐Heterocyclic Carbene (NHC) Ligand and its Application in a Green Pharmaceutical Context

A large‐scale synthesis of known Ru olefin metathesis catalyst VII featuring an unsymmetrical N‐heterocyclic carbene (NHC) ligand with one 2,5‐diisopropylphenyl (DIPP) and one thiophenylmethylene N‐substituent is reported. The optimised procedure does not require column chromatography in any step an...

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Veröffentlicht in:	Chemistry : a European journal 2020-12, Vol.26 (67), p.15708-15717
Hauptverfasser:	Nienałtowski, Tomasz, Szczepanik, Paweł, Małecki, Paweł, Czajkowska‐Szczykowska, Dorota, Czarnocki, Stefan, Pawłowska, Jolanta, Kajetanowicz, Anna, Grela, Karol
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Catalysts Chemical synthesis Chemistry Column chromatography Contamination Green Chemistry Technology large-scale synthesis Ligands medicinal chemistry Metathesis Methane - analogs & derivatives Methane - chemistry N-heterocyclic carbene (NHC) ligands olefin metathesis Organometallic Compounds - chemistry Ruthenium - chemistry ruthenium catalysts Sildenafil Substrates
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