Piezo1 regulates migration and invasion of breast cancer cells via modulating cell mechanobiological properties

Piezo1 regulates migration and invasion of breast cancer cells via modulating cell mechanobiological properties

Abstract Cell migration and invasion are two essential processes during cancer metastasis. Increasing evidence has shown that the Piezo1 channel is involved in mediating cell migration and invasion in some types of cancers. However, the role of Piezo1 in the breast cancer and its underlying mechanis...

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Veröffentlicht in:Acta biochimica et biophysica Sinica 2021-01, Vol.53 (1), p.10-18
Hauptverfasser: Yu, Yang, Wu, Xiao’an, Liu, Sisi, Zhao, Hongping, Li, Bo, Zhao, Hucheng, Feng, Xiqiao
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container_title Acta biochimica et biophysica Sinica
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creator Yu, Yang
Wu, Xiao’an
Liu, Sisi
Zhao, Hongping
Li, Bo
Zhao, Hucheng
Feng, Xiqiao
description Abstract Cell migration and invasion are two essential processes during cancer metastasis. Increasing evidence has shown that the Piezo1 channel is involved in mediating cell migration and invasion in some types of cancers. However, the role of Piezo1 in the breast cancer and its underlying mechanisms have not been clarified yet. Here, we show that Piezo1 is high-expressed in breast cancer cell (BCC) lines, despite its complex expression in clinical patient database. Piezo1 knockdown (Piezo1-KD) promotes unconfined BCC migration, but impedes confined cell migration. Piezo1 may mediate BCC migration through the balances of cell adhesion, cell stiffness, and contractility. Furthermore, Piezo1-KD inhibits BCC invasion by impairing the invadopodium formation and suppressing the expression of metalloproteinases (MMPs) as well. However, the proliferation and cell cycle of BCCs are not significantly affected by Piezo1. Our study highlights a crucial role of Piezo1 in regulating migration and invasion of BCCs, indicating Piezo1 channel might be a new prognostic and therapeutic target in BCCs.
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title Piezo1 regulates migration and invasion of breast cancer cells via modulating cell mechanobiological properties
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