The Bromodomain Inhibitor PFI-3 Sensitizes Cancer Cells to DNA Damage by Targeting SWI/SNF

Many chemotherapeutic drugs produce double-strand breaks (DSB) on cancer cell DNA, thereby inducing cell death. However, the DNA damage response (DDR) enables cancer cells to overcome DNA damage and escape cell death, often leading to therapeutic resistance and unsuccessful outcomes. It is therefore...

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Veröffentlicht in:	Molecular cancer research 2021-05, Vol.19 (5), p.900-912
Hauptverfasser:	Lee, Daye, Lee, Da-Yeon, Hwang, You-Son, Seo, Hye-Ran, Lee, Shin-Ai, Kwon, Jongbum
Format:	Artikel
Sprache:	eng
Schlagworte:	Azabicyclo Compounds - antagonists & inhibitors Azabicyclo Compounds - pharmacology Azabicyclo Compounds - therapeutic use Chromosomal Proteins, Non-Histone - genetics DNA Damage - genetics Humans Protein Domains - genetics Pyridines - antagonists & inhibitors Pyridines - pharmacology Pyridines - therapeutic use Transcription Factors - genetics
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