Thyrotropin Receptor-Specific Lymphocytes in Adenovirus-TSHR-Immunized Native and Human Leukocyte Antigen-DR3-Transgenic Mice and in Graves' Disease Patient Blood

Background: Antigen-specific lymphocytes are increasingly investigated in autoimmune diseases and immune therapies. We sought to identify thyrotropin receptor (TSHR)-specific lymphocytes in mouse models of Graves' disease, including Graves' patient-specific immunotype human leukocyte antig...

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Veröffentlicht in:	Thyroid (New York, N.Y.) N.Y.), 2021-06, Vol.31 (6), p.95-963
Hauptverfasser:	Degen, Heidrun, Gavvovidis, Ioannis, Blankenstein, Thomas, Uhland, Kerstin, Ungerer, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology CD40 Ligand - immunology Disease Models, Animal Epitopes - immunology Graves Disease - immunology Histocompatibility Antigens Class II - immunology HLA-DR3 Antigen - genetics Humans Hyperthyroidism - immunology Immunization Immunology, Autoimmunity, and Graves’ Ophthalmopathy Immunophenotyping Interferon-gamma - immunology Interleukin-1beta - immunology Interleukin-6 - immunology Mice Mice, Transgenic Peptides Receptors, Thyrotropin - immunology T-Lymphocytes, Regulatory - immunology Tumor Necrosis Factor-alpha - immunology
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